Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane.

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Title: Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane.
Authors: Soteriou C; School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK; Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, UK; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Xu M; School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK., Connell SD; Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, UK; Astbury Center for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK., Tyler AII; School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK., Kalli AC; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK; Astbury Center for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. Electronic address: a.kalli@leeds.ac.uk., Thorne JL; School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK. Electronic address: j.l.thorne@leeds.ac.uk.
Source: Structure (London, England : 1993) [Structure] 2025 Jan 02; Vol. 33 (1), pp. 181-195.e5. Date of Electronic Publication: 2024 Nov 05.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE
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  Data: Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane.
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  Data: <searchLink fieldCode="AU" term="%22Soteriou+C%22">Soteriou C</searchLink>; School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK; Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, UK; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK.<br /><searchLink fieldCode="AU" term="%22Connell+SD%22">Connell SD</searchLink>; Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, UK; Astbury Center for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.<br /><searchLink fieldCode="AU" term="%22Tyler+AII%22">Tyler AII</searchLink>; School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK.<br /><searchLink fieldCode="AU" term="%22Kalli+AC%22">Kalli AC</searchLink>; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK; Astbury Center for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. Electronic address: a.kalli@leeds.ac.uk.<br /><searchLink fieldCode="AU" term="%22Thorne+JL%22">Thorne JL</searchLink>; School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK. Electronic address: j.l.thorne@leeds.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101087697%22">Structure (London, England : 1993)</searchLink> [Structure] 2025 Jan 02; Vol. 33 (1), pp. 181-195.e5. <i>Date of Electronic Publication: </i>2024 Nov 05.
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