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The effect of methylation on the let-7-BCL2L1-BCL2 axis and the potential use of hypomethylating and BH3 mimetic drugs in histiocytic neoplasms.

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Title: The effect of methylation on the let-7-BCL2L1-BCL2 axis and the potential use of hypomethylating and BH3 mimetic drugs in histiocytic neoplasms.
Authors: Salmon-Divon M; Department of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel, Israel.; Adelson School of Medicine, Ariel University, Ariel, Israel., Meyuchas R; Department of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel, Israel.; Translational Research Lab, Assuta Medical Centers, Tel-Aviv, Israel., Shpilberg O; Adelson School of Medicine, Ariel University, Ariel, Israel.; Translational Research Lab, Assuta Medical Centers, Tel-Aviv, Israel.; Clinic of Histiocytic Neoplasms, Institute of Hematology, Assuta Medical Center, Tel-Aviv, Israel., Okon E; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Benhamida J; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yabe M; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Petrova-Drus K; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zvida-Bloch T; Department of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel, Israel.; Translational Research Lab, Assuta Medical Centers, Tel-Aviv, Israel., Basood M; Clinic of Histiocytic Neoplasms, Institute of Hematology, Assuta Medical Center, Tel-Aviv, Israel., Mazor R; Clinic of Histiocytic Neoplasms, Institute of Hematology, Assuta Medical Center, Tel-Aviv, Israel., Durham BH; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Haroche J; Service de Médecine Interne, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Sorbonne Université, Faculté de Médecine, Paris, France., Abdel-Wahab O; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Diamond EL; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. diamone1@mskcc.org., Hershkovitz-Rokah O; Department of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel, Israel. oshratr@assuta.co.il.; Translational Research Lab, Assuta Medical Centers, Tel-Aviv, Israel. oshratr@assuta.co.il.
Source: Leukemia [Leukemia] 2025 Feb; Vol. 39 (2), pp. 516-519. Date of Electronic Publication: 2024 Nov 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:1476-5551
DOI:10.1038/s41375-024-02459-5