Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.
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| Title: | Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction. |
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| Authors: | Braun A; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Shekhar S; Department of Genetics, University of North Carolina at Chapel Hill, North Carolina, USA.; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Levey DF; Department of Psychiatry, Yale School of Medicine, West Haven, CT, USA.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Straub P; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Kraft J; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Panagiotaropoulou GM; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Heilbron K; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Awasthi S; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Meleka Hanna R; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany., Hoffmann S; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany., Stein M; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, USA., Lehnerer S; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany., Mergenthaler P; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Elnahas AG; Institute of Genomics, University of Tartu, Tartu, Estonia., Topaloudi A; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Koromina M; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Palviainen T; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Asbjornsdottir B; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Stefansson H; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Skuladóttir AT; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Jónsdóttir I; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Stefansson K; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Reis K; Institute of Genomics, University of Tartu, Tartu, Estonia., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia., Palotie A; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Leypoldt F; Department of Neurology, Kiel University, Kiel, Schleswig-Holstein, Germany., Stein MB; Department of Psychiatry and School of Public Health, University of California San Diego, La Jolla, California, USA.; Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, California, USA., Fontanillas P; 23andMe, Inc., Sunnyvale, California, USA., Kaprio J; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Gelernter J; Department of Psychiatry, Yale School of Medicine, West Haven, CT, USA.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Davis LK; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Paschou P; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Tannemaat MR; Leiden University Medical Center, Department of Neurology, Leiden, Zuid Holland, Netherlands., Verschuuren JJGM; Leiden University Medical Center, Department of Neurology, Leiden, Zuid Holland, Netherlands., Kuhlenbäumer G; Department of Neurology, Kiel University, Kiel, Schleswig-Holstein, Germany.; Neuroimmunology, Kiel University, Institute of Clinical Chemistry, Kiel, Schleswig-Holstein, Germany., Gregersen PK; Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, NY, USA., Huijbers MG; Leiden University Medical Center, Department of Neurology, Leiden, Zuid Holland, Netherlands.; Leiden University Medical Center, Department of Human Genetics, Leiden, Zuid Holland, Netherlands., Stascheit F; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany., Meisel A; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany., Ripke S; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany. sripke@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. sripke@broadinstitute.org.; German Center for Mental Health (DZPG), partner site Berlin/Potsdam, Berlin, Germany. sripke@broadinstitute.org. |
| Corporate Authors: | Estonian Biobank Research Team, 23andMe Research Team |
| Source: | Nature communications [Nat Commun] 2024 Nov 13; Vol. 15 (1), pp. 9839. Date of Electronic Publication: 2024 Nov 13. |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-53595-6 |
