Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations.

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Title: Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations.
Authors: Nishijima S; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Stankevic E; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Aasmets O; Institute of Genomics, University of Tartu, Tartu, Estonia., Schmidt TSB; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Nagata N; Department of Gastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan., Keller MI; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Ferretti P; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Juel HB; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Fullam A; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Robbani SM; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Schudoma C; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Hansen JK; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark., Holm LA; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark., Israelsen M; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark., Schierwagen R; Department of Internal Medicine B, University of Münster, Münster, Germany., Torp N; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark., Telzerow A; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Hercog R; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Kandels S; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Hazenbrink DHM; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Arumugam M; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Bendtsen F; Gastrounit, Medical Division, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Brøns C; Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark., Fonvig CE; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Holm JC; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nielsen T; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Medical department, University Hospital Zeeland, Køge, Denmark., Pedersen JS; Gastrounit, Medical Division, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Thiele MS; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark., Trebicka J; Department of Internal Medicine B, University of Münster, Münster, Germany; European Foundation for the Study of Chronic Liver Failure, EFCLIF, Barcelona, Spain., Org E; Institute of Genomics, University of Tartu, Tartu, Estonia., Krag A; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Kuhn M; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. Electronic address: mkuhn@embl.de., Bork P; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany; Max Delbrück Centre for Molecular Medicine, Berlin, Germany; Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany. Electronic address: peer.bork@embl.org.
Corporate Authors: GALAXY and MicrobLiver Consortia
Source: Cell [Cell] 2025 Jan 09; Vol. 188 (1), pp. 222-236.e15. Date of Electronic Publication: 2024 Nov 13.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2024.10.022