Phase I Clinical Study of a Multi-Kinase Inhibitor TG02 Capsule for the Treatment of Recurrent High-Grade Gliomas with Failed Temozolomide Treatment in Chinese Patients.

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Title: Phase I Clinical Study of a Multi-Kinase Inhibitor TG02 Capsule for the Treatment of Recurrent High-Grade Gliomas with Failed Temozolomide Treatment in Chinese Patients.
Authors: Guo CC; Department of Neurosurgery/Neuro-Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China., Yang QY; Department of Neurosurgery/Neuro-Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China., Xi SY; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.; Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, China., Zhou J; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.; Department of Radiology, Sun Yat-Sen University Cancer Center, Guangzhou, China., Zhou ZH; Department of Neurosurgery/Neuro-Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China., Cao X; Department of Neurosurgery/Neuro-Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China., Liao YX; Department of Neurosurgery/Neuro-Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China., Li BX; Lee's Pharmaceutical Holdings Limited, Hong Kong, Hong Kong, China., Dai XR; Lee's Pharmaceutical Holdings Limited, Hong Kong, Hong Kong, China., Wong M; Lee's Pharmaceutical Holdings Limited, Hong Kong, Hong Kong, China., Li YJ; Lee's Pharmaceutical Holdings Limited, Hong Kong, Hong Kong, China., Yu XH; Guangzhou Hankewei Pharmaceutical Technology Co. Ltd, Guangzhou, China., Chen ZP; Department of Neurosurgery/Neuro-Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.
Source: Chemotherapy [Chemotherapy] 2025; Vol. 70 (2), pp. 74-84. Date of Electronic Publication: 2024 Nov 18.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Karger Country of Publication: Switzerland NLM ID: 0144731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9794 (Electronic) Linking ISSN: 00093157 NLM ISO Abbreviation: Chemotherapy Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1421-9794
DOI:10.1159/000542365