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Oxaliplatin and 5-fluorouracil promote epithelial-mesenchymal transition via activation of KRAS/ERK/NF-κB pathway in KRAS-mutated colon cancer cells.

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Title: Oxaliplatin and 5-fluorouracil promote epithelial-mesenchymal transition via activation of KRAS/ERK/NF-κB pathway in KRAS-mutated colon cancer cells.
Authors: Hoshida T; Kindai University Faculty of Pharmacy, Kowakae, Higashiosaka, Osaka, 577-8502, Japan.; Department of Pharmacy, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Wakayama, Japan., Tsubaki M; Laboratory of Pharmacotherapy, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Shido, Sanuki, Kagawa, 769-2193, Japan., Takeda T; Kindai University Faculty of Pharmacy, Kowakae, Higashiosaka, Osaka, 577-8502, Japan., Asano R; Kindai University Faculty of Pharmacy, Kowakae, Higashiosaka, Osaka, 577-8502, Japan., Choi IH; Kindai University Faculty of Pharmacy, Kowakae, Higashiosaka, Osaka, 577-8502, Japan., Takimoto K; Kindai University Faculty of Pharmacy, Kowakae, Higashiosaka, Osaka, 577-8502, Japan., Inukai A; Kindai University Faculty of Pharmacy, Kowakae, Higashiosaka, Osaka, 577-8502, Japan., Imano M; Department of Surgery, Kindai University School of Medicine, Osakasayama, Osaka, 589-8511, Japan., Tanabe K; Department of Pharmacy, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Wakayama, Japan., Nagai N; Kindai University Faculty of Pharmacy, Kowakae, Higashiosaka, Osaka, 577-8502, Japan., Nishida S; Kindai University Faculty of Pharmacy, Kowakae, Higashiosaka, Osaka, 577-8502, Japan. nishida@phar.kindai.ac.jp.
Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2025 May; Vol. 480 (5), pp. 2985-2999. Date of Electronic Publication: 2024 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1573-4919
DOI:10.1007/s11010-024-05157-z