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Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.

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Title: Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.
Authors: Engel MG; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA., Narayan S; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA., Cui MH; Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA., Branch CA; Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA., Zhang X; Computational Genomics Core, Albert Einstein College of Medicine, Bronx, NY, USA., Gandy SE; Department of Neurology and the Mount Sinai Center for Cognitive Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry and the Mount Sinai Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ehrlich M; Department of Neurology and the Mount Sinai Center for Cognitive Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry and the Mount Sinai Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Huffman DM; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2025 Jan; Vol. 103 (1), pp. 113-126. Date of Electronic Publication: 2024 Nov 29.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1875-8908
DOI:10.1177/13872877241299056