Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.

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Title: Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.
Authors: Engel MG; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA., Narayan S; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA., Cui MH; Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA., Branch CA; Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA., Zhang X; Computational Genomics Core, Albert Einstein College of Medicine, Bronx, NY, USA., Gandy SE; Department of Neurology and the Mount Sinai Center for Cognitive Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry and the Mount Sinai Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ehrlich M; Department of Neurology and the Mount Sinai Center for Cognitive Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry and the Mount Sinai Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Huffman DM; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2025 Jan; Vol. 103 (1), pp. 113-126. Date of Electronic Publication: 2024 Nov 29.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.
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  Data: <searchLink fieldCode="AU" term="%22Engel+MG%22">Engel MG</searchLink>; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Narayan+S%22">Narayan S</searchLink>; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cui+MH%22">Cui MH</searchLink>; Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Branch+CA%22">Branch CA</searchLink>; Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Computational Genomics Core, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gandy+SE%22">Gandy SE</searchLink>; Department of Neurology and the Mount Sinai Center for Cognitive Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry and the Mount Sinai Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ehrlich+M%22">Ehrlich M</searchLink>; Department of Neurology and the Mount Sinai Center for Cognitive Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry and the Mount Sinai Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Huffman+DM%22">Huffman DM</searchLink>; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
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  Data: <searchLink fieldCode="JN" term="%229814863%22">Journal of Alzheimer's disease : JAD</searchLink> [J Alzheimers Dis] 2025 Jan; Vol. 103 (1), pp. 113-126. <i>Date of Electronic Publication: </i>2024 Nov 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9814863 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1875-8908 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213872877%22">13872877 </searchLink><i>NLM ISO Abbreviation: </i>J Alzheimers Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1177/13872877241299056
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        Text: English
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      – TitleFull: Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.
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              Text: 2025 Jan
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