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Xenogeneic-free culture of human intestinal stem cells on functional polymer-coated substrates for scalable, clinical-grade stem cell therapy.

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Title: Xenogeneic-free culture of human intestinal stem cells on functional polymer-coated substrates for scalable, clinical-grade stem cell therapy.
Authors: Park S; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea., Kwon O; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea., Lee H; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea., Cho Y; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea., Yeun J; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea., Yoon SH; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea., Sun SY; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea., Huh Y; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea., Yu WD; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea., Park S; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea., Son N; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea., Jeon S; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea., Lee S; Digital Biotech Innovation Center, KRIBB, Daejeon, Republic of Korea., Kim DS; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.; Digital Biotech Innovation Center, KRIBB, Daejeon, Republic of Korea., Lee SY; Nanobio Measurement Group, Division of Biomedical Metrology, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea., Son JG; Nanobio Measurement Group, Division of Biomedical Metrology, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea., Lee KJ; R&D Institute, ORGANOIDSCIENCES Ltd., Seongnam, Republic of Korea., Kim YI; R&D Institute, ORGANOIDSCIENCES Ltd., Seongnam, Republic of Korea., Lim JH; Department of Surgery, Gangnam Severance Hospital, Pancreatobiliary Cancer Clinic, Yonsei University College of Medicine, Seoul, Republic of Korea., Yoo J; R&D Institute, ORGANOIDSCIENCES Ltd., Seongnam, Republic of Korea.; Organoid Standards Initiative (OSI), Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Republic of Korea.; CHA Organoid Research Center, CHA University, Seongnam, Republic of Korea., Lee TG; Nanobio Measurement Group, Division of Biomedical Metrology, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea., Son MY; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea. myson@kribb.re.kr.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea. myson@kribb.re.kr.; Organoid Standards Initiative (OSI), Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Republic of Korea. myson@kribb.re.kr.; School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea. myson@kribb.re.kr., Im SG; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea. sgim@kaist.ac.kr.; KAIST Stem Cell Center, Department of Chemical and Biomolecular Engineering, Graduate School of Stem Cell & Regenerative Biology, KAIST, Daejeon, Republic of Korea. sgim@kaist.ac.kr.
Source: Nature communications [Nat Commun] 2024 Dec 02; Vol. 15 (1), pp. 10492. Date of Electronic Publication: 2024 Dec 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Xenogeneic-free culture of human intestinal stem cells on functional polymer-coated substrates for scalable, clinical-grade stem cell therapy.
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  Data: <searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+O%22">Kwon O</searchLink>; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+Y%22">Cho Y</searchLink>; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yeun+J%22">Yeun J</searchLink>; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+SH%22">Yoon SH</searchLink>; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Sun+SY%22">Sun SY</searchLink>; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Huh+Y%22">Huh Y</searchLink>; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yu+WD%22">Yu WD</searchLink>; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Son+N%22">Son N</searchLink>; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+S%22">Jeon S</searchLink>; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Digital Biotech Innovation Center, KRIBB, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+DS%22">Kim DS</searchLink>; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.; Digital Biotech Innovation Center, KRIBB, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SY%22">Lee SY</searchLink>; Nanobio Measurement Group, Division of Biomedical Metrology, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Son+JG%22">Son JG</searchLink>; Nanobio Measurement Group, Division of Biomedical Metrology, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+KJ%22">Lee KJ</searchLink>; R&D Institute, ORGANOIDSCIENCES Ltd., Seongnam, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+YI%22">Kim YI</searchLink>; R&D Institute, ORGANOIDSCIENCES Ltd., Seongnam, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lim+JH%22">Lim JH</searchLink>; Department of Surgery, Gangnam Severance Hospital, Pancreatobiliary Cancer Clinic, Yonsei University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yoo+J%22">Yoo J</searchLink>; R&D Institute, ORGANOIDSCIENCES Ltd., Seongnam, Republic of Korea.; Organoid Standards Initiative (OSI), Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Republic of Korea.; CHA Organoid Research Center, CHA University, Seongnam, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+TG%22">Lee TG</searchLink>; Nanobio Measurement Group, Division of Biomedical Metrology, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Son+MY%22">Son MY</searchLink>; Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea. myson@kribb.re.kr.; KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea. myson@kribb.re.kr.; Organoid Standards Initiative (OSI), Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Republic of Korea. myson@kribb.re.kr.; School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea. myson@kribb.re.kr.<br /><searchLink fieldCode="AU" term="%22Im+SG%22">Im SG</searchLink>; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea. sgim@kaist.ac.kr.; KAIST Stem Cell Center, Department of Chemical and Biomolecular Engineering, Graduate School of Stem Cell & Regenerative Biology, KAIST, Daejeon, Republic of Korea. sgim@kaist.ac.kr.
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