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Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach.

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Title: Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach.
Authors: de Jong JCBC; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands. j.dejong@tno.nl.; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands. j.dejong@tno.nl.; Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands. j.dejong@tno.nl., Caspers MPM; Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands., Dulos R; Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands., Snabel J; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands., van der Hoek MD; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands.; Applied Research Centre Food and Dairy, Van Hall Larenstein University of Applied Sciences, Leeuwarden, The Netherlands.; MCL Academy, Medical Centre Leeuwarden, Leeuwarden, The Netherlands., van der Leij FR; Applied Research Centre Food and Dairy, Van Hall Larenstein University of Applied Sciences, Leeuwarden, The Netherlands.; RIC-AFL Inholland University of Applied Sciences, Delft and Amsterdam, The Netherlands., Kleemann R; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands., Keijer J; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands., Nieuwenhuizen AG; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands., van den Hoek AM; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands., Verschuren L; Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
Source: GeroScience [Geroscience] 2025 Jun; Vol. 47 (3), pp. 3741-3758. Date of Electronic Publication: 2024 Dec 03.
Publication Type: Journal Article; Validation Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach.
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  Data: <searchLink fieldCode="AU" term="%22de+Jong+JCBC%22">de Jong JCBC</searchLink>; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands. j.dejong@tno.nl.; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands. j.dejong@tno.nl.; Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands. j.dejong@tno.nl.<br /><searchLink fieldCode="AU" term="%22Caspers+MPM%22">Caspers MPM</searchLink>; Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Dulos+R%22">Dulos R</searchLink>; Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Snabel+J%22">Snabel J</searchLink>; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Hoek+MD%22">van der Hoek MD</searchLink>; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands.; Applied Research Centre Food and Dairy, Van Hall Larenstein University of Applied Sciences, Leeuwarden, The Netherlands.; MCL Academy, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Leij+FR%22">van der Leij FR</searchLink>; Applied Research Centre Food and Dairy, Van Hall Larenstein University of Applied Sciences, Leeuwarden, The Netherlands.; RIC-AFL Inholland University of Applied Sciences, Delft and Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kleemann+R%22">Kleemann R</searchLink>; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Keijer+J%22">Keijer J</searchLink>; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nieuwenhuizen+AG%22">Nieuwenhuizen AG</searchLink>; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Hoek+AM%22">van den Hoek AM</searchLink>; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Verschuren+L%22">Verschuren L</searchLink>; Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2025 Jun; Vol. 47 (3), pp. 3741-3758. <i>Date of Electronic Publication: </i>2024 Dec 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101686284 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2509-2723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225092723%22">25092723 </searchLink><i>NLM ISO Abbreviation: </i>Geroscience <i>Subsets: </i>MEDLINE
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              Text: 2025 Jun
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