The gut microbial metabolite phenylacetylglutamine increases susceptibility to atrial fibrillation after myocardial infarction through ferroptosis and NLRP3 inflammasome.

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Title: The gut microbial metabolite phenylacetylglutamine increases susceptibility to atrial fibrillation after myocardial infarction through ferroptosis and NLRP3 inflammasome.
Authors: Wang G; Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., He Q; Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Shuai W; Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China.; Cardiovascular Research Institute of Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China., Yang H; Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China.; Cardiovascular Research Institute of Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China., Kong B; Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China.; Cardiovascular Research Institute of Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China., Lu S; Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China., Gong Y; Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China. gongyangcn@whu.edu.cn.; Cardiovascular Research Institute of Wuhan University, Wuhan, China. gongyangcn@whu.edu.cn.; Hubei Key Laboratory of Cardiology, Wuhan, China. gongyangcn@whu.edu.cn.
Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2025 Feb; Vol. 30 (1-2), pp. 210-225. Date of Electronic Publication: 2024 Dec 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1573-675X
DOI:10.1007/s10495-024-02046-0