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Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease.

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Title: Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease.
Authors: Dinkel L; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany., Hummel S; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Zenatti V; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany., Malara M; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany., Tillmann Y; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany., Colombo A; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany., Monasor LS; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany., Suh JH; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Logan T; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Roth S; Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, 81377 Munich, Germany., Paeger L; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany., Hoffelner P; Department of Physiological Genomics, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.; Graduate School of Systemic Neurosciences, Ludwig Maximilian University, 82152 Planegg-Martinsried, Germany., Bludau O; Department of Physiological Genomics, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany., Schmidt A; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.; Graduate School of Systemic Neurosciences, Ludwig Maximilian University, 82152 Planegg-Martinsried, Germany.; Neuroproteomics School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany., Müller SA; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.; Neuroproteomics School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany., Schifferer M; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany., Nuscher B; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Njavro JR; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany., Prestel M; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany., Bartos LM; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Wind-Mark K; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Slemann L; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Hoermann L; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Kunte ST; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Gnörich J; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Lindner S; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Simons M; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.; Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.; Institute of Neuronal Cell Biology (TUM-NZB), Technical University of Munich, 80802 Munich, Germany., Herms J; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University München, 81377 Munich, Germany., Paquet D; Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany., Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.; Neuroproteomics School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany., Bartenstein P; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Franzmeier N; Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.; Department of Psychiatry and Neurochemistry, University of Gothenburg, Sahlgrenska Academy, Institute of Neuroscience and Physiology, SE-413 90 Mölndal and Gothenburg, Sweden., Liesz A; Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany., Grosche A; Department of Physiological Genomics, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany., Bremova-Ertl T; Department of Neurology, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Department of Neurology, University Hospital Bern, 3010 Bern, Switzerland., Catarino C; Friedrich Baur Institute, Department of Neurology, LMU University Hospital, LMU Munich, 80336 Munich, Germany., Beblo S; Center for Pediatric Research Leipzig, Department of Women and Child Health, Hospital for Children and Adolescents, University Hospital Leipzig; Leipzig University Center for Rare Diseases, 04103 Leipzig, Germany., Bergner C; Department of Neurology, University Hospital Leipzig, 04103 Leipzig, Germany., Schneider SA; Department of Neurology, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Strupp M; Department of Neurology, LMU University Hospital, LMU Munich, 81377 Munich, Germany., Di Paolo G; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Brendel M; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany., Tahirovic S; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.
Source: Science translational medicine [Sci Transl Med] 2024 Dec 04; Vol. 16 (776), pp. eadl4616. Date of Electronic Publication: 2024 Dec 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.adl4616