Lithium normalizes ASD-related neuronal, synaptic, and behavioral phenotypes in DYRK1A-knockin mice.

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Title: Lithium normalizes ASD-related neuronal, synaptic, and behavioral phenotypes in DYRK1A-knockin mice.
Authors: Roh JD; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, 34141, Korea., Bae M; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, 34141, Korea., Kim H; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, 34141, Korea., Yang Y; Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, 34141, Korea.; Digital Omics Research Center, Korea Basic Science Institute, Cheongju, 28119, Korea., Lee Y; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, 34141, Korea.; Korea Institute of Drug Safety & Risk Management, Anyang, 14051, Korea., Cho Y; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, 41940, Korea., Lee S; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, 34141, Korea., Li Y; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, 34141, Korea., Yang E; Department of Anatomy and BK21 Graduate Program, Biomedical Sciences, College of Medicine, Korea University, Seoul, 02841, Korea., Jang H; Bertis Inc, Gwacheon, 13840, Korea., Kim H; Bertis Inc, Gwacheon, 13840, Korea., Kim H; Department of Anatomy and BK21 Graduate Program, Biomedical Sciences, College of Medicine, Korea University, Seoul, 02841, Korea., Kang H; Division of National Supercomputing, KISTI, Daejeon, 34141, Korea., Ellegood J; Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, M5T 3H7, Canada.; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, M4G 1R8, Canada., Lerch JP; Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, M5T 3H7, Canada.; Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, Oxfordshire, OX39DU, UK., Bae YC; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, 41940, Korea., Kim JY; Digital Omics Research Center, Korea Basic Science Institute, Cheongju, 28119, Korea., Kim E; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, 34141, Korea. kime@kaist.ac.kr.; Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, 34141, Korea. kime@kaist.ac.kr.
Source: Molecular psychiatry [Mol Psychiatry] 2025 Jun; Vol. 30 (6), pp. 2584-2596. Date of Electronic Publication: 2024 Dec 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-024-02865-2