Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade.
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| Title: | Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade. |
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| Authors: | Chen CB; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan.; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Chang Gung Immunology Consortium, Chang Gung University, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan.; Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.; School of Medicine, National Tsing Hua University, Hsinchu, Taiwan.; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China.; Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, China., Hung SI; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Institute of Pharmacology, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan., Chang JW; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Division of Hematology-Oncology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Yang CK; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Division of Hematology-Oncology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Ma DH; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Limbal Stem Cell Laboratory, Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Teng YC; Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan., Lu CW; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Chen WT; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Yang HY; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Cancer and Immunology Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Tsai CC; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Wang CL; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Division of Pulmonary Oncology and Interventional Bronchoscopy, Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan., Chiang PH; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Dermatology, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan., Wu J; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Tsai YW; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Lu LY; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Lin YY; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Hui RC; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Hsieh FM; Biotools Co. Ltd, New Taipei City, Taiwan., Hsu CK; Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Lee CN; Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Chen YJ; Institute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan.; Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan., Chen CC; Institute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan.; Department of Dermatology, Taipei Veterans General Hospital, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Cui Y; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Hsu HC; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Division of Hematology-Oncology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Chang YC; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Chang CJ; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China.; Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, China.; Medical Research Center, Xiamen Chang Gung Hospital, Xiamen, China.; School of Medicine, Huaqiao University, Quanzhou, China., Lin HC; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Chang CJ; Research Services Center for Health Information, Chang Gung University, Taoyuan, Taiwan.; Clinical Informatics and Medical Statistics Research Center, Chang Gung University, Taoyuan, Taiwan., Lin YJ; Research Services Center for Health Information, Chang Gung University, Taoyuan, Taiwan.; Clinical Informatics and Medical Statistics Research Center, Chang Gung University, Taoyuan, Taiwan., Ku CL; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. Clku@cgu.edu.tw.; Chang Gung Immunology Consortium, Chang Gung University, Taoyuan, Taiwan. Clku@cgu.edu.tw.; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Clku@cgu.edu.tw.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Clku@cgu.edu.tw.; Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan. Clku@cgu.edu.tw.; Center for Molecular and Clinical and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Clku@cgu.edu.tw.; Division of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. Clku@cgu.edu.tw., Wang CW; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. kiruamairo@gmail.com.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. kiruamairo@gmail.com.; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. kiruamairo@gmail.com.; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. kiruamairo@gmail.com.; Chang Gung Immunology Consortium, Chang Gung University, Taoyuan, Taiwan. kiruamairo@gmail.com.; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China. kiruamairo@gmail.com.; Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, China. kiruamairo@gmail.com.; Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan, Taiwan. kiruamairo@gmail.com., Chung WH; Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. wenhungchung@yahoo.com.; Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. wenhungchung@yahoo.com.; Department of Dermatology, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan. wenhungchung@yahoo.com.; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. wenhungchung@yahoo.com.; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. wenhungchung@yahoo.com.; Chang Gung Immunology Consortium, Chang Gung University, Taoyuan, Taiwan. wenhungchung@yahoo.com.; College of Medicine, Chang Gung University, Taoyuan, Taiwan. wenhungchung@yahoo.com.; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan. wenhungchung@yahoo.com.; Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. wenhungchung@yahoo.com.; School of Medicine, National Tsing Hua University, Hsinchu, Taiwan. wenhungchung@yahoo.com.; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China. wenhungchung@yahoo.com.; Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, China. wenhungchung@yahoo.com.; Department of Dermatology, Beijing Tsinghua Chang Gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. wenhungchung@yahoo.com.; Department of Dermatology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. wenhungchung@yahoo.com. |
| Source: | Nature communications [Nat Commun] 2024 Dec 30; Vol. 15 (1), pp. 10733. Date of Electronic Publication: 2024 Dec 30. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-54180-7 |
