SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection.
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| Title: | SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection. |
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| Authors: | Richards A; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA., Khalil AS; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02215, USA.; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA., Friesen M; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA., Whitfield TW; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA., Gao X; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA., Lungjangwa T; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA., Kamm RD; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Wan Z; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Gehrke L; Department of Microbiology, Harvard Medical School, Boston, MA, 02115, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Mooney D; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA. mooneyd@seas.harvard.edu.; Department of Microbiology, Harvard Medical School, Boston, MA, 02115, USA. mooneyd@seas.harvard.edu., Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA. jaenisch@wi.mit.edu.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. jaenisch@wi.mit.edu. |
| Source: | Nature communications [Nat Commun] 2024 Dec 30; Vol. 15 (1), pp. 10754. Date of Electronic Publication: 2024 Dec 30. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-54917-4 |
