Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma.

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Title: Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma.
Authors: Fathi Kazerooni A; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA. anahitaf@upenn.edu.; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA. anahitaf@upenn.edu.; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. anahitaf@upenn.edu.; Department of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. anahitaf@upenn.edu., Kraya A; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Rathi KS; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kim MC; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Vossough A; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Khalili N; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Familiar AM; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Gandhi D; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Khalili N; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kesherwani V; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Haldar D; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA., Anderson H; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Jin R; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Mahtabfar A; Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA., Bagheri S; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Guo Y; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Li Q; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Huang X; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Zhu Y; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Sickler A; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Lueder MR; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Phul S; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Koptyra M; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Storm PB; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Ware JB; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Song Y; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Raymond G. Perelman Center for Cellular and Molecular Therapeutics, University of Pennsylvania, Philadelphia, PA, USA., Davatzikos C; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Foster JB; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mueller S; Department of Neurology and Pediatrics, University of California San Francisco, San Francisco, CA, USA., Fisher MJ; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Resnick AC; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Nabavizadeh A; Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Ali.Nabavizadeh@pennmedicine.upenn.edu.; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Ali.Nabavizadeh@pennmedicine.upenn.edu.
Source: Nature communications [Nat Commun] 2025 Jan 02; Vol. 16 (1), pp. 340. Date of Electronic Publication: 2025 Jan 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-024-55659-z