Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth.

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Title: Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth.
Authors: Pollock KM; Imperial College London, Department of Infectious Disease, UK; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Cheeseman HM; Imperial College London, Department of Infectious Disease, UK., McFarlane LR; Imperial College London, Department of Infectious Disease, UK., Day S; Imperial College London, Department of Infectious Disease, UK., Tolazzi M; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Joypooranachandran J; Imperial College London, Department of Infectious Disease, UK., Shramko K; Imperial College London, Department of Infectious Disease, UK., Dispinseri S; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Mundsperger P; Polymun Scientific Immunbiologische Forschung GmbH, Klosterneuburg, Austria., Bontjer I; Department of Medical Microbiology, Academic Medical Centre University of Amsterdam, Amsterdam, the Netherlands., Lemm NM; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Coelho S; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Tanaka M; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Cole T; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Korber B; New Mexico Consortium, Los Alamos, NM, USA., Katinger D; Polymun Scientific Immunbiologische Forschung GmbH, Klosterneuburg, Austria., Sattentau QJ; The Sir William Dunn School of Pathology, The University of Oxford, Oxford, UK., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Scarlatti G; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Sanders RW; Department of Medical Microbiology, Academic Medical Centre University of Amsterdam, Amsterdam, the Netherlands., Shattock RJ; Imperial College London, Department of Infectious Disease, UK. Electronic address: r.shattock@ic.ac.uk.
Source: EBioMedicine [EBioMedicine] 2025 Feb; Vol. 112, pp. 105544. Date of Electronic Publication: 2025 Jan 02.
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2352-3964
DOI:10.1016/j.ebiom.2024.105544