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Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth.

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Title: Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth.
Authors: Pollock KM; Imperial College London, Department of Infectious Disease, UK; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Cheeseman HM; Imperial College London, Department of Infectious Disease, UK., McFarlane LR; Imperial College London, Department of Infectious Disease, UK., Day S; Imperial College London, Department of Infectious Disease, UK., Tolazzi M; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Joypooranachandran J; Imperial College London, Department of Infectious Disease, UK., Shramko K; Imperial College London, Department of Infectious Disease, UK., Dispinseri S; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Mundsperger P; Polymun Scientific Immunbiologische Forschung GmbH, Klosterneuburg, Austria., Bontjer I; Department of Medical Microbiology, Academic Medical Centre University of Amsterdam, Amsterdam, the Netherlands., Lemm NM; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Coelho S; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Tanaka M; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Cole T; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Korber B; New Mexico Consortium, Los Alamos, NM, USA., Katinger D; Polymun Scientific Immunbiologische Forschung GmbH, Klosterneuburg, Austria., Sattentau QJ; The Sir William Dunn School of Pathology, The University of Oxford, Oxford, UK., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Scarlatti G; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Sanders RW; Department of Medical Microbiology, Academic Medical Centre University of Amsterdam, Amsterdam, the Netherlands., Shattock RJ; Imperial College London, Department of Infectious Disease, UK. Electronic address: r.shattock@ic.ac.uk.
Source: EBioMedicine [EBioMedicine] 2025 Feb; Vol. 112, pp. 105544. Date of Electronic Publication: 2025 Jan 02.
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth.
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  Data: <searchLink fieldCode="AU" term="%22Pollock+KM%22">Pollock KM</searchLink>; Imperial College London, Department of Infectious Disease, UK; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Cheeseman+HM%22">Cheeseman HM</searchLink>; Imperial College London, Department of Infectious Disease, UK.<br /><searchLink fieldCode="AU" term="%22McFarlane+LR%22">McFarlane LR</searchLink>; Imperial College London, Department of Infectious Disease, UK.<br /><searchLink fieldCode="AU" term="%22Day+S%22">Day S</searchLink>; Imperial College London, Department of Infectious Disease, UK.<br /><searchLink fieldCode="AU" term="%22Tolazzi+M%22">Tolazzi M</searchLink>; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Turner+HL%22">Turner HL</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Joypooranachandran+J%22">Joypooranachandran J</searchLink>; Imperial College London, Department of Infectious Disease, UK.<br /><searchLink fieldCode="AU" term="%22Shramko+K%22">Shramko K</searchLink>; Imperial College London, Department of Infectious Disease, UK.<br /><searchLink fieldCode="AU" term="%22Dispinseri+S%22">Dispinseri S</searchLink>; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mundsperger+P%22">Mundsperger P</searchLink>; Polymun Scientific Immunbiologische Forschung GmbH, Klosterneuburg, Austria.<br /><searchLink fieldCode="AU" term="%22Bontjer+I%22">Bontjer I</searchLink>; Department of Medical Microbiology, Academic Medical Centre University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lemm+NM%22">Lemm NM</searchLink>; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Coelho+S%22">Coelho S</searchLink>; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Tanaka+M%22">Tanaka M</searchLink>; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Cole+T%22">Cole T</searchLink>; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Korber+B%22">Korber B</searchLink>; New Mexico Consortium, Los Alamos, NM, USA.<br /><searchLink fieldCode="AU" term="%22Katinger+D%22">Katinger D</searchLink>; Polymun Scientific Immunbiologische Forschung GmbH, Klosterneuburg, Austria.<br /><searchLink fieldCode="AU" term="%22Sattentau+QJ%22">Sattentau QJ</searchLink>; The Sir William Dunn School of Pathology, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Scarlatti+G%22">Scarlatti G</searchLink>; Viral Evolution and Transmission Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sanders+RW%22">Sanders RW</searchLink>; Department of Medical Microbiology, Academic Medical Centre University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Shattock+RJ%22">Shattock RJ</searchLink>; Imperial College London, Department of Infectious Disease, UK. Electronic address: r.shattock@ic.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101647039%22">EBioMedicine</searchLink> [EBioMedicine] 2025 Feb; Vol. 112, pp. 105544. <i>Date of Electronic Publication: </i>2025 Jan 02.
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  Data: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101647039 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-3964 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223523964%22">23523964 </searchLink><i>NLM ISO Abbreviation: </i>EBioMedicine <i>Subsets: </i>MEDLINE
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