Acute Myeloid Leukemia Skews Therapeutic WT1-specific CD8 TCR-T Cells Towards an NK-like Phenotype that Compromises Function and Persistence.

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Title: Acute Myeloid Leukemia Skews Therapeutic WT1-specific CD8 TCR-T Cells Towards an NK-like Phenotype that Compromises Function and Persistence.
Authors: Mazziotta F; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Immunotherapy Integrated Research Center, Fred Hutch Cancer Center, Seattle, WA, USA., Martin LE; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Eagan DN; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Division of Medical Oncology, University of Washington, Seattle, WA, USA., Bar M; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Division of Medical Oncology, University of Washington, Seattle, WA, USA.; Bristol Myers Squibb., Kinsella S; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Paulson KG; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Division of Medical Oncology, University of Washington, Seattle, WA, USA., Voillet V; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Cape Town HVTN Immunology Laboratory, Hutchinson Centre Research Institute of South Africa, Cape Town, South Africa., Lahman MC; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Hunter D; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Schmitt TM; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Duerkopp N; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Yeung C; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Tang TH; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Gottardo R; Biomedical Data Science Center, Lausanne University Hospital.; University of Lausanne, Lausanne, Switzerland.; Agora Translational Research Center, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Asano Y; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Wilcox EC; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Lee B; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Zhang T; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Lopedote P; Department of Medicine, St. Elizabeth's Medical Center, Boston University, Boston, MA, USA., Penter L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Digital Clinician Scientist Program, Berlin, Germany., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Milano F; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Immunotherapy Integrated Research Center, Fred Hutch Cancer Center, Seattle, WA, USA., Greenberg PD; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Departments of Immunology and Medicine, University of Washington, Seattle, WA, USA., Chapuis AG; Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Immunotherapy Integrated Research Center, Fred Hutch Cancer Center, Seattle, WA, USA.; Division of Medical Oncology, University of Washington, Seattle, WA, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Dec 16. Date of Electronic Publication: 2024 Dec 16.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2024.12.13.24318504