Loading of CAR-T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism.

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Title: Loading of CAR-T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism.
Authors: Pfister F; Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany., Carnell LR; Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany., Löffler L; Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany., Boosz P; Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany., Schaft N; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.; Department of Dermatology Universitätsklinikum Erlangen Erlangen Germany.; Comprehensive Cancer Center Erlangen European Metropolitan Area of Nuremberg (CCC ER-EMN) Erlangen Germany.; Deutsches Zentrum Immuntherapie (DZI) Erlangen Germany., Dörrie J; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.; Department of Dermatology Universitätsklinikum Erlangen Erlangen Germany.; Comprehensive Cancer Center Erlangen European Metropolitan Area of Nuremberg (CCC ER-EMN) Erlangen Germany.; Deutsches Zentrum Immuntherapie (DZI) Erlangen Germany., Stein R; Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany., Lenz M; Institute of Micro- and Nanostructure Research & Center for Nanoanalysis and Electron Microscopy Interdisciplinary Center for Nanostructured Films Friedrich-Alexander-University Erlangen Erlangen Germany., Spiecker E; Institute of Micro- and Nanostructure Research & Center for Nanoanalysis and Electron Microscopy Interdisciplinary Center for Nanostructured Films Friedrich-Alexander-University Erlangen Erlangen Germany., Huber CM; Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.; Institute of Microwave and Photonics Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany., Haddadin S; Chair of Robotics Science and Systems Intelligence Munich Institute of Robotics and Machine Intelligence (MIRMI), TUM School of Computation, Information and Technology Technical University of Munich Munich Germany., Berking C; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.; Department of Dermatology Universitätsklinikum Erlangen Erlangen Germany.; Comprehensive Cancer Center Erlangen European Metropolitan Area of Nuremberg (CCC ER-EMN) Erlangen Germany.; Deutsches Zentrum Immuntherapie (DZI) Erlangen Germany., Alexiou C; Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany., Janko C; Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.
Source: MedComm [MedComm (2020)] 2025 Jan 05; Vol. 6 (1), pp. e70039. Date of Electronic Publication: 2025 Jan 05 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: China NLM ID: 101769925 Publication Model: eCollection Cited Medium: Internet ISSN: 2688-2663 (Electronic) Linking ISSN: 26882663 NLM ISO Abbreviation: MedComm (2020) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2688-2663
DOI:10.1002/mco2.70039