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Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors.

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Title: Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors.
Authors: Nicolle S; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Barker M; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Barrett J; In Vitro In Vivo Translation, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Campbell M; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Wojno-Picon J; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Atkinson SJ; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Aylott H; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Kessedjian H; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., He Y; Medicine Development and Supply, GlaxoSmithKline R&D Hub, 1250 South Collegeville Road, Upper Providence, Pennsylvania 19426, United States., Messenger C; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Roberts E; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Spitzfaden C; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Le J; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Zinn N; Cellzome GmbH, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg 69117, Germany., Werner T; Cellzome GmbH, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg 69117, Germany., Dümpelfeld B; Cellzome GmbH, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg 69117, Germany., Bantscheff M; Cellzome GmbH, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg 69117, Germany., Somers DO; Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Reid H; Immunology Research Unit GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Thang K; Immunology Research Unit GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Gobbetti T; Immunology Research Unit GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Lewis HD; Immunology Research Unit GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Jan 23; Vol. 68 (2), pp. 1883-1900. Date of Electronic Publication: 2025 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.4c02630