Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study.
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| Title: | Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study. |
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| Authors: | Kudo M; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan., Ren Z; Department of Hepatic Oncology, Zhongshan Hospital, Fudan University, Shanghai, China., Guo Y; Nanfang Hospital, Guangzhou Southern Medical University, Guangzhou, China., Han G; Department of Liver Diseases and Digestive Interventional Radiology, Digestive Diseases Hospital, Xi'an International Medical Center Hospital, Northwest University, Xi'an, China., Lin H; Department of Tumor Interventional Radiology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, China., Zheng J; Department of Hepatobiliary and Pancreatic Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China., Ogasawara S; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan., Kim JH; Department of Gastroenterology and Hepatology, Korea University Guro Hospital, Seoul, South Korea., Zhao H; Department of Liver Surgery, Peking Union Medical College Hospital, Dongcheng, Beijing, China., Li C; Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Madoff DC; Department of Radiology and Biomedical Imaging, Section of Interventional Radiology, Yale School of Medicine, New Haven, CT, USA., Ghobrial RM; Sherrie and Alan Conover Center for Liver Disease and Transplantation, J C Walter Jr Center for Transplantation, Houston Methodist Hospital, Houston, TX, USA., Kawaoka T; Department of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Gerolami R; Aix-Marseille Université, IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille, France; Assistance Publique-Hôpitaux de Marseille (AP-HM), Hôpital de la Timone, Unité d'hépatologie, Marseille, France., Ikeda M; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Kumada H; Department of Hepatology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo, Japan., El-Khoueiry AB; USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Vogel A; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hanover, Germany; Department of Gastroenterology and Hepatology, Toronto General Hospital, Medical Oncology, UHN Princess Margaret Cancer Centre, Toronto, ON, Canada., Peng X; Merck & Co, Inc, Rahway, NJ, USA., Mody K; Eisai, Nutley, NJ, USA., Dutcus C; Eisai, Nutley, NJ, USA., Dubrovsky L; Merck & Co, Inc, Rahway, NJ, USA., Siegel AB; Merck & Co, Inc, Rahway, NJ, USA., Finn RS; Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Llovet JM; Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Liver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain. Electronic address: josep.llovet@mountsinai.org. |
| Corporate Authors: | LEAP-012 investigators |
| Source: | Lancet (London, England) [Lancet] 2025 Jan 18; Vol. 405 (10474), pp. 203-215. Date of Electronic Publication: 2025 Jan 08. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39798578 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kudo+M%22">Kudo M</searchLink>; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ren+Z%22">Ren Z</searchLink>; Department of Hepatic Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; Nanfang Hospital, Guangzhou Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Han+G%22">Han G</searchLink>; Department of Liver Diseases and Digestive Interventional Radiology, Digestive Diseases Hospital, Xi'an International Medical Center Hospital, Northwest University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Lin+H%22">Lin H</searchLink>; Department of Tumor Interventional Radiology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Zheng+J%22">Zheng J</searchLink>; Department of Hepatobiliary and Pancreatic Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.<br /><searchLink fieldCode="AU" term="%22Ogasawara+S%22">Ogasawara S</searchLink>; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Kim+JH%22">Kim JH</searchLink>; Department of Gastroenterology and Hepatology, Korea University Guro Hospital, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Department of Liver Surgery, Peking Union Medical College Hospital, Dongcheng, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Madoff+DC%22">Madoff DC</searchLink>; Department of Radiology and Biomedical Imaging, Section of Interventional Radiology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Ghobrial+RM%22">Ghobrial RM</searchLink>; Sherrie and Alan Conover Center for Liver Disease and Transplantation, J C Walter Jr Center for Transplantation, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kawaoka+T%22">Kawaoka T</searchLink>; Department of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Gerolami+R%22">Gerolami R</searchLink>; Aix-Marseille Université, IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille, France; Assistance Publique-Hôpitaux de Marseille (AP-HM), Hôpital de la Timone, Unité d'hépatologie, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Ikeda+M%22">Ikeda M</searchLink>; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Kumada+H%22">Kumada H</searchLink>; Department of Hepatology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22El-Khoueiry+AB%22">El-Khoueiry AB</searchLink>; USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vogel+A%22">Vogel A</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hanover, Germany; Department of Gastroenterology and Hepatology, Toronto General Hospital, Medical Oncology, UHN Princess Margaret Cancer Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Peng+X%22">Peng X</searchLink>; Merck & Co, Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Mody+K%22">Mody K</searchLink>; Eisai, Nutley, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Dutcus+C%22">Dutcus C</searchLink>; Eisai, Nutley, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Dubrovsky+L%22">Dubrovsky L</searchLink>; Merck & Co, Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Siegel+AB%22">Siegel AB</searchLink>; Merck & Co, Inc, Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Finn+RS%22">Finn RS</searchLink>; Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Llovet+JM%22">Llovet JM</searchLink>; Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Liver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain. Electronic address: josep.llovet@mountsinai.org. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22LEAP-012+investigators%22">LEAP-012 investigators</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2025 Jan 18; Vol. 405 (10474), pp. 203-215. <i>Date of Electronic Publication: </i>2025 Jan 08. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985213R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-547X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201406736%22">01406736 </searchLink><i>NLM ISO Abbreviation: </i>Lancet <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39798578 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S0140-6736(24)02575-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 203 Titles: – TitleFull: Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kudo M – PersonEntity: Name: NameFull: Ren Z – PersonEntity: Name: NameFull: Guo Y – PersonEntity: Name: NameFull: Han G – PersonEntity: Name: NameFull: Lin H – PersonEntity: Name: NameFull: Zheng J – PersonEntity: Name: NameFull: Ogasawara S – PersonEntity: Name: NameFull: Kim JH – PersonEntity: Name: NameFull: Zhao H – PersonEntity: Name: NameFull: Li C – PersonEntity: Name: NameFull: Madoff DC – PersonEntity: Name: NameFull: Ghobrial RM – PersonEntity: Name: NameFull: Kawaoka T – PersonEntity: Name: NameFull: Gerolami R – PersonEntity: Name: NameFull: Ikeda M – PersonEntity: Name: NameFull: Kumada H – PersonEntity: Name: NameFull: El-Khoueiry AB – PersonEntity: Name: NameFull: Vogel A – PersonEntity: Name: NameFull: Peng X – PersonEntity: Name: NameFull: Mody K – PersonEntity: Name: NameFull: Dutcus C – PersonEntity: Name: NameFull: Dubrovsky L – PersonEntity: Name: NameFull: Siegel AB – PersonEntity: Name: NameFull: Finn RS – PersonEntity: Name: NameFull: Llovet JM IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 01 Text: 2025 Jan 18 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1474-547X Numbering: – Type: volume Value: 405 – Type: issue Value: 10474 Titles: – TitleFull: Lancet (London, England) Type: main |
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