Design, synthesis, in vitro, and in silico studies of novel isatin-hybrid hydrazones as potential triple-negative breast cancer agents.

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Title: Design, synthesis, in vitro, and in silico studies of novel isatin-hybrid hydrazones as potential triple-negative breast cancer agents.
Authors: Munir I; Institute of Chemical Sciences, Bahauddin Zakariya University Multan-60800 Pakistan zahidshafiq@bzu.edu.pk., Batool Z; Institute of Chemical Sciences, Bahauddin Zakariya University Multan-60800 Pakistan zahidshafiq@bzu.edu.pk., Khan F; Department of Pharmacy, Abdul Wali Khan University Mardan KPK Pakistan aharrasi@unizwa.edu.om.; Natural and Medical Sciences Research Centre, University of Nizwa P. O. Box 33, PC 616, Birkat Al Mauz Nizwa Sultanate of Oman., Hussain J; Department of Biological Sciences and Chemistry, University of Nizwa Oman., Khan A; Natural and Medical Sciences Research Centre, University of Nizwa P. O. Box 33, PC 616, Birkat Al Mauz Nizwa Sultanate of Oman.; Department of Chemical and Biological Engineering, College of Engineering, Korea University 145 Anam-ro, Seongbuk-gu Seoul 02841 Republic of Korea., Mali SN; School of Pharmacy, DY Patil Deemed To Be University Navi Mumbai India., Radhakrishnan VV; Dept. Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham Cochin India., Mathew B; Dept. Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham Cochin India., Almutairi TM; Department of Chemistry, College of Science, King Saud University Riyadh 11451 Saudi Arabia., Al-Harrasi A; Natural and Medical Sciences Research Centre, University of Nizwa P. O. Box 33, PC 616, Birkat Al Mauz Nizwa Sultanate of Oman., Akram MS; School of Science & Health, Teesside University Middlesbrough TS1 3BA UK.; National Horizons Centre, Teesside University 38 John Dixon Ln Darlington DL1 1HG UK., Shafiq Z; Institute of Chemical Sciences, Bahauddin Zakariya University Multan-60800 Pakistan zahidshafiq@bzu.edu.pk.
Source: RSC advances [RSC Adv] 2025 Jan 13; Vol. 15 (2), pp. 948-965. Date of Electronic Publication: 2025 Jan 13 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2046-2069
DOI:10.1039/d4ra07650h