Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing.

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Title: Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing.
Authors: Kong G; Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK., Song Y; Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK., Yan Y; Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK., Calderazzo SM; Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Boston University Alzheimer's Disease and CTE Centers, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Saddala MS; Department of Neurobiology and Behaviour, School of Biological Sciences, University of California Irvine, Irvine, CA, USA., De Labastida Rivera F; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Cherry JD; Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Boston University Alzheimer's Disease and CTE Centers, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Eckman N; Department of Chemical Engineering, Stanford University, Stanford, CA, USA; Department of Materials Science & Engineering, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Paediatrics, Endocrinology, Stanford University, Stanford, CA, USA; ChEM-H Institute, Stanford University, Stanford, CA, USA; Woods Institute for the Environment, Stanford University, Stanford, CA, USA., Appel EA; Department of Chemical Engineering, Stanford University, Stanford, CA, USA; Department of Materials Science & Engineering, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Paediatrics, Endocrinology, Stanford University, Stanford, CA, USA; ChEM-H Institute, Stanford University, Stanford, CA, USA; Woods Institute for the Environment, Stanford University, Stanford, CA, USA., Velenosi A; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada; Praxis Spinal Cord Institute, Vancouver, BC, Canada., Swarup V; Department of Neurobiology and Behaviour, School of Biological Sciences, University of California Irvine, Irvine, CA, USA., Kawaguchi R; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Semel Institute for Neuroscience and Human Behaviour, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Ng SS; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Institute of Experimental Oncology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany., Kwon BK; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada; Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada., Gate D; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Engwerda CR; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Zhou L; Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK; Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: l.zhou13@imperial.ac.uk., Di Giovanni S; Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK. Electronic address: s.di-giovanni@imperial.ac.uk.
Source: Neuron [Neuron] 2025 Mar 05; Vol. 113 (5), pp. 684-700.e8. Date of Electronic Publication: 2025 Jan 13.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4199
DOI:10.1016/j.neuron.2024.12.012