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Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants.

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Title: Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants.
Authors: Stratakis N; Institute for Global Health (ISGlobal), Barcelona, Spain. nikos.stratakis@isglobal.org.; Universitat Pompeu Fabra (UPF), Barcelona, Spain. nikos.stratakis@isglobal.org.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. nikos.stratakis@isglobal.org., Anguita-Ruiz A; Institute for Global Health (ISGlobal), Barcelona, Spain.; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona (UB), Barcelona, Spain.; CIBEROBN (Physiopathology of Obesity and Nutrition Network CB12/03/30038), Institute of Health Carlos III (ISCIII), Madrid, Spain., Fabbri L; Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Maitre L; Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., González JR; Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Andrusaityte S; Department of Environmental Sciences, Vytautas Magnus University, Kaunas, Lithuania., Basagaña X; Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Borràs E; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain., Keun HC; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Cancer Metabolism & Systems Toxicology Group, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom., Chatzi L; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Conti DV; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Goodrich J; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Grazuleviciene R; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona (UB), Barcelona, Spain., Haug LS; Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway.; Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway., Heude B; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), F-75004, Paris, France., Yuan WL; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), F-75004, Paris, France., McEachan R; Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, United Kingdom., Nieuwenhuijsen M; Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Sabidó E; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain., Slama R; Department of Prevention and Treatment of Chronic Diseases, Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Grenoble, France., Thomsen C; Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway.; Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway., Urquiza J; Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Roumeliotaki T; Department of Social Medicine, University of Crete, Heraklion, Crete, Greece., Vafeiadi M; Department of Social Medicine, University of Crete, Heraklion, Crete, Greece., Wright J; Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, United Kingdom., Bustamante M; Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Vrijheid M; Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Source: Nature communications [Nat Commun] 2025 Jan 14; Vol. 16 (1), pp. 654. Date of Electronic Publication: 2025 Jan 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-56013-7