Intralesional injection of CpG ODNs complexed with glatiramer acetate mitigates systemic cytokine toxicities and synergistically advances checkpoint blockade efficacy.
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| Title: | Intralesional injection of CpG ODNs complexed with glatiramer acetate mitigates systemic cytokine toxicities and synergistically advances checkpoint blockade efficacy. |
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| Authors: | Gong H; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA., Griffin JD; Kinimmune, Inc. St. Louis, 63141, Missouri, USA., Groer CE; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA., Wu X; Department of Molecular Biosciences, The University of Kansas, 66045, Lawrence, KS, USA., Li M; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA., Abdelaziz MM; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA., Xu L; Department of Molecular Biosciences, The University of Kansas, 66045, Lawrence, KS, USA., Forrest ML; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA., Berkland CJ; Kinimmune, Inc. St. Louis, 63141, Missouri, USA. coryb@wustl.edu.; Department of Biomedical Engineering, Washington University, 63105, Saint Louis, Missouri, USA. coryb@wustl.edu.; Department of Chemistry, Washington University, 63105, Saint Louis, Missouri, USA. coryb@wustl.edu. |
| Source: | Drug delivery and translational research [Drug Deliv Transl Res] 2026 Jun; Vol. 16 (6), pp. 1736-1753. Date of Electronic Publication: 2025 Jan 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2190-3948 |
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| DOI: | 10.1007/s13346-025-01798-9 |
