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Intralesional injection of CpG ODNs complexed with glatiramer acetate mitigates systemic cytokine toxicities and synergistically advances checkpoint blockade efficacy.

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Title: Intralesional injection of CpG ODNs complexed with glatiramer acetate mitigates systemic cytokine toxicities and synergistically advances checkpoint blockade efficacy.
Authors: Gong H; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA., Griffin JD; Kinimmune, Inc. St. Louis, 63141, Missouri, USA., Groer CE; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA., Wu X; Department of Molecular Biosciences, The University of Kansas, 66045, Lawrence, KS, USA., Li M; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA., Abdelaziz MM; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA., Xu L; Department of Molecular Biosciences, The University of Kansas, 66045, Lawrence, KS, USA., Forrest ML; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA., Berkland CJ; Kinimmune, Inc. St. Louis, 63141, Missouri, USA. coryb@wustl.edu.; Department of Biomedical Engineering, Washington University, 63105, Saint Louis, Missouri, USA. coryb@wustl.edu.; Department of Chemistry, Washington University, 63105, Saint Louis, Missouri, USA. coryb@wustl.edu.
Source: Drug delivery and translational research [Drug Deliv Transl Res] 2026 Jun; Vol. 16 (6), pp. 1736-1753. Date of Electronic Publication: 2025 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intralesional injection of CpG ODNs complexed with glatiramer acetate mitigates systemic cytokine toxicities and synergistically advances checkpoint blockade efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Gong+H%22">Gong H</searchLink>; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA.<br /><searchLink fieldCode="AU" term="%22Griffin+JD%22">Griffin JD</searchLink>; Kinimmune, Inc. St. Louis, 63141, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Groer+CE%22">Groer CE</searchLink>; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Molecular Biosciences, The University of Kansas, 66045, Lawrence, KS, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA.<br /><searchLink fieldCode="AU" term="%22Abdelaziz+MM%22">Abdelaziz MM</searchLink>; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Department of Molecular Biosciences, The University of Kansas, 66045, Lawrence, KS, USA.<br /><searchLink fieldCode="AU" term="%22Forrest+ML%22">Forrest ML</searchLink>; Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, KS, USA.<br /><searchLink fieldCode="AU" term="%22Berkland+CJ%22">Berkland CJ</searchLink>; Kinimmune, Inc. St. Louis, 63141, Missouri, USA. coryb@wustl.edu.; Department of Biomedical Engineering, Washington University, 63105, Saint Louis, Missouri, USA. coryb@wustl.edu.; Department of Chemistry, Washington University, 63105, Saint Louis, Missouri, USA. coryb@wustl.edu.
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        Value: 10.1007/s13346-025-01798-9
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        Text: English
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      – TitleFull: Intralesional injection of CpG ODNs complexed with glatiramer acetate mitigates systemic cytokine toxicities and synergistically advances checkpoint blockade efficacy.
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              Text: 2026 Jun
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