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Derivatization of ophiobolin A and cytotoxicity toward breast and glioblastoma cancer stem cells: Varying the ketone and unsaturated aldehyde moieties.

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Title: Derivatization of ophiobolin A and cytotoxicity toward breast and glioblastoma cancer stem cells: Varying the ketone and unsaturated aldehyde moieties.
Authors: Aroujo J; Department of Chemistry and Biochemistry, Baylor University, 101 Bagby Ave., Waco, TX 76798, United States., Parker H; Department of Biology, Baylor University, 101 Bagby Ave., Waco, TX 76798, United States., Boari A; Institute of Sciences of Food Production, National Research Council, Via Amendola 122/O, 70125 Bari, Italy., Mason E; Department of Chemistry and Biochemistry, Baylor University, 101 Bagby Ave., Waco, TX 76798, United States., Otakpor MU; Department of Chemistry and Biochemistry, Texas State University, 601 University Dr., TX 78666, United States., Betancourt T; Department of Chemistry and Biochemistry, Texas State University, 601 University Dr., TX 78666, United States., Kornienko A; Department of Chemistry and Biochemistry, Texas State University, 601 University Dr., TX 78666, United States. Electronic address: a_k76@txstate.edu., Ciavatta ML; Institute of Biomolecular Chemistry, National Research Council (CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy., Carbone M; Institute of Biomolecular Chemistry, National Research Council (CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy., Evidente A; Institute of Biomolecular Chemistry, National Research Council (CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy. Electronic address: evidente@unina.it., Taube JH; Department of Biology, Baylor University, 101 Bagby Ave., Waco, TX 76798, United States. Electronic address: Joseph_Taube@baylor.edu., Romo D; Department of Chemistry and Biochemistry, Baylor University, 101 Bagby Ave., Waco, TX 76798, United States. Electronic address: Daniel_Romo@baylor.edu.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 May 01; Vol. 120, pp. 130112. Date of Electronic Publication: 2025 Jan 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Derivatization of ophiobolin A and cytotoxicity toward breast and glioblastoma cancer stem cells: Varying the ketone and unsaturated aldehyde moieties.
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  Data: <searchLink fieldCode="AU" term="%22Aroujo+J%22">Aroujo J</searchLink>; Department of Chemistry and Biochemistry, Baylor University, 101 Bagby Ave., Waco, TX 76798, United States.<br /><searchLink fieldCode="AU" term="%22Parker+H%22">Parker H</searchLink>; Department of Biology, Baylor University, 101 Bagby Ave., Waco, TX 76798, United States.<br /><searchLink fieldCode="AU" term="%22Boari+A%22">Boari A</searchLink>; Institute of Sciences of Food Production, National Research Council, Via Amendola 122/O, 70125 Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Mason+E%22">Mason E</searchLink>; Department of Chemistry and Biochemistry, Baylor University, 101 Bagby Ave., Waco, TX 76798, United States.<br /><searchLink fieldCode="AU" term="%22Otakpor+MU%22">Otakpor MU</searchLink>; Department of Chemistry and Biochemistry, Texas State University, 601 University Dr., TX 78666, United States.<br /><searchLink fieldCode="AU" term="%22Betancourt+T%22">Betancourt T</searchLink>; Department of Chemistry and Biochemistry, Texas State University, 601 University Dr., TX 78666, United States.<br /><searchLink fieldCode="AU" term="%22Kornienko+A%22">Kornienko A</searchLink>; Department of Chemistry and Biochemistry, Texas State University, 601 University Dr., TX 78666, United States. Electronic address: a_k76@txstate.edu.<br /><searchLink fieldCode="AU" term="%22Ciavatta+ML%22">Ciavatta ML</searchLink>; Institute of Biomolecular Chemistry, National Research Council (CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.<br /><searchLink fieldCode="AU" term="%22Carbone+M%22">Carbone M</searchLink>; Institute of Biomolecular Chemistry, National Research Council (CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.<br /><searchLink fieldCode="AU" term="%22Evidente+A%22">Evidente A</searchLink>; Institute of Biomolecular Chemistry, National Research Council (CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy. Electronic address: evidente@unina.it.<br /><searchLink fieldCode="AU" term="%22Taube+JH%22">Taube JH</searchLink>; Department of Biology, Baylor University, 101 Bagby Ave., Waco, TX 76798, United States. Electronic address: Joseph_Taube@baylor.edu.<br /><searchLink fieldCode="AU" term="%22Romo+D%22">Romo D</searchLink>; Department of Chemistry and Biochemistry, Baylor University, 101 Bagby Ave., Waco, TX 76798, United States. Electronic address: Daniel_Romo@baylor.edu.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2025 May 01; Vol. 120, pp. 130112. <i>Date of Electronic Publication: </i>2025 Jan 27.
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