Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics.

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Title: Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics.
Authors: Ritter M; Dept. of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurological Surgery, Washington University in St. Louis School of Medicine, St. Louis, MI, USA., Blume C; Dept. of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurological Surgery, Washington University in St. Louis School of Medicine, St. Louis, MI, USA., Tang Y; Dept. of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Patel A; Dept. of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurological Surgery, Washington University in St. Louis School of Medicine, St. Louis, MI, USA., Patel B; Dept. of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Berghaus N; Dept. of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Kada Benotmane J; Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany.; Microenvironment and Immunology Research Laboratory, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany.; Translational Neurosurgery, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany., Kueckelhaus J; Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany.; Microenvironment and Immunology Research Laboratory, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany.; Translational Neurosurgery, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany., Yabo Y; Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany.; Microenvironment and Immunology Research Laboratory, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany.; Translational Neurosurgery, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany., Zhang J; Translational Neurosurgery, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany.; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Medicine, Freiburg University, Freiburg, Germany., Grabis E; Translational Neurosurgery, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany.; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Medicine, Freiburg University, Freiburg, Germany., Villa G; Microenvironment and Immunology Research Laboratory, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany.; Translational Neurosurgery, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany., Zimmer DN; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Medicine, Freiburg University, Freiburg, Germany., Khriesh A; Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany., Sievers P; Dept. of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Seferbekova Z; Division of AI in Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hinz F; Dept. of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Ravi VM; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Medicine, Freiburg University, Freiburg, Germany., Seiz-Rosenhagen M; Department of Neurosurgery, Hospital Memmingen, Memmingen, Germany., Ratliff M; Department of Neurosurgery, University Medicine Mannheim, University of Heidelberg, Mannheim, Germany., Herold-Mende C; Division of Experimental Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany., Schnell O; Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Beck J; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Medicine, Freiburg University, Freiburg, Germany., Wick W; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany., von Deimling A; Dept. of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Gerstung M; Division of AI in Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Heiland DH; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. henrik.heiland@uk-erlangen.de.; Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany. henrik.heiland@uk-erlangen.de.; Microenvironment and Immunology Research Laboratory, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany. henrik.heiland@uk-erlangen.de.; Translational Neurosurgery, Friedrich-Alexander Universität Nürnberg-Erlangen, Erlangen, Germany. henrik.heiland@uk-erlangen.de.; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany. henrik.heiland@uk-erlangen.de.; Faculty of Medicine, Freiburg University, Freiburg, Germany. henrik.heiland@uk-erlangen.de.; German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany. henrik.heiland@uk-erlangen.de., Sahm F; Dept. of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany. Felix.sahm@med.uni-heidelberg.de.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Felix.sahm@med.uni-heidelberg.de.
Source: Nature cancer [Nat Cancer] 2025 Feb; Vol. 6 (2), pp. 292-306. Date of Electronic Publication: 2025 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-1347
DOI:10.1038/s43018-024-00904-z