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Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection.

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Title: Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection.
Authors: Warner BM; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Vendramelli R; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Boese AS; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Audet J; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Tailor N; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Meilleur C; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Glowach N; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada., Willman M; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada., Truong T; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Moffat E; National Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada., Tierney K; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Kosak B; Orion Biotechnology Polska, Krakow, Poland., Dhanidina I; Orion Biotechnology, Ottawa, Ontario, Canada., Engstrom J; Orion Biotechnology, Ottawa, Ontario, Canada., Korczak B; Orion Biotechnology Polska, Krakow, Poland., McGowan I; Orion Biotechnology Polska, Krakow, Poland., Embury-Hyatt C; National Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada., Kobasa D; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.
Source: PloS one [PLoS One] 2025 Feb 05; Vol. 20 (2), pp. e0316952. Date of Electronic Publication: 2025 Feb 05 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
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  Data: Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection.
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  Data: <searchLink fieldCode="AU" term="%22Warner+BM%22">Warner BM</searchLink>; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Vendramelli+R%22">Vendramelli R</searchLink>; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Boese+AS%22">Boese AS</searchLink>; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Audet+J%22">Audet J</searchLink>; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Tailor+N%22">Tailor N</searchLink>; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Meilleur+C%22">Meilleur C</searchLink>; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Glowach+N%22">Glowach N</searchLink>; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Willman+M%22">Willman M</searchLink>; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Truong+T%22">Truong T</searchLink>; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Moffat+E%22">Moffat E</searchLink>; National Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Tierney+K%22">Tierney K</searchLink>; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Kosak+B%22">Kosak B</searchLink>; Orion Biotechnology Polska, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Dhanidina+I%22">Dhanidina I</searchLink>; Orion Biotechnology, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Engstrom+J%22">Engstrom J</searchLink>; Orion Biotechnology, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Korczak+B%22">Korczak B</searchLink>; Orion Biotechnology Polska, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22McGowan+I%22">McGowan I</searchLink>; Orion Biotechnology Polska, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Embury-Hyatt+C%22">Embury-Hyatt C</searchLink>; National Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Kobasa+D%22">Kobasa D</searchLink>; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2025 Feb 05; Vol. 20 (2), pp. e0316952. <i>Date of Electronic Publication: </i>2025 Feb 05 (<i>Print Publication: </i>2025).
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