Genetic architecture in Greenland is shaped by demography, structure and selection.

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Title: Genetic architecture in Greenland is shaped by demography, structure and selection.
Authors: Stæger FF; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark., Andersen MK; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Li Z; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark., Hjerresen JP; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., He S; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark., Santander CG; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark., Jensen RT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rex KF; Department of Internal Medicine, Queen Ingrid's Hospital, Nuuk, Greenland.; Department of Clinical Medicine, Arctic Health Research Centre, Aalborg University Hospital, Aalborg, Denmark., Thuesen ACB; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hanghøj K; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark., Seiding IH; Ilisimatusarfik - University of Greenland, Nuuk, Greenland., Jørsboe E; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Stinson SE; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rasmussen MS; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark., Balboa RF; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark., Larsen CVL; Centre for Public Health in Greenland, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.; Greenland Center for Health Research, Institute for Health and Nature, University of Greenland, Nuuk, Greenland., Bjerregaard P; Centre for Public Health in Greenland, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark., Schubert M; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Meisner J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; TUM School of Medicine and Heath, Technical University of Munich (TUM) and Klinikum Rechts der Isar, Munich, Germany., Nielsen R; Departments of Integrative Biology and Statistics, University of California at Berkeley, California, CA, USA.; GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Jørgensen ME; Centre for Public Health in Greenland, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.; Greenland Center for Health Research, Institute for Health and Nature, University of Greenland, Nuuk, Greenland.; Steno Diabetes Center Greenland, Nuuk, Greenland., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. torben.hansen@sund.ku.dk., Moltke I; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark. ida@bio.ku.dk., Albrechtsen A; Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark. aalbrechtsen@bio.ku.dk.
Source: Nature [Nature] 2025 Mar; Vol. 639 (8054), pp. 404-410. Date of Electronic Publication: 2025 Feb 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-024-08516-4