Imaging Clusters of Pediatric Low-Grade Glioma Are Associated with Distinct Molecular Characteristics.

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Title: Imaging Clusters of Pediatric Low-Grade Glioma Are Associated with Distinct Molecular Characteristics.
Authors: Fathi Kazerooni A; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania anahitaf@upenn.edu.; AID Center for AI and Data Science for Integrated Diagnostics (A.F.K.), University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Kraya A; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Rathi KS; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Kim MC; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Kesherwani V; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Corbett R; Center for Cancer and Immunology Research (R.C.), Children's National Hospital, Washington, District of Columbia.; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, District of Columbia., Vossough A; Division of Radiology (A.V.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Khalili N; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Gandhi D; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Khalili N; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Familiar AM; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Jin R; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Huang X; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Zhu Y; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Sickler A; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Lueder MR; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Pathology and Laboratory Medicine (M.R.L.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Phul S; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Storm PB; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Ware JB; Department of Radiology (A.N., J.B.W.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Foster JB; Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Pediatrics (J.B.F.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Mueller S; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, California., Rokita JL; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, District of Columbia., Fisher MJ; Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Resnick AC; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Nabavizadeh A; From the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Neurosurgery (A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Radiology (A.N., J.B.W.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Source: AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2025 Aug 01; Vol. 46 (8), pp. 1716-1725. Date of Electronic Publication: 2025 Aug 01.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Neuroradiology Country of Publication: United States NLM ID: 8003708 Publication Model: Electronic Cited Medium: Internet ISSN: 1936-959X (Electronic) Linking ISSN: 01956108 NLM ISO Abbreviation: AJNR Am J Neuroradiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1936-959X
DOI:10.3174/ajnr.A8699