Thymine as potential biomarker to predict 5-FU systemic exposure in patients with gastro-intestinal cancer: a prospective pharmacokinetic study (FUUT-trial).

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Title: Thymine as potential biomarker to predict 5-FU systemic exposure in patients with gastro-intestinal cancer: a prospective pharmacokinetic study (FUUT-trial).
Authors: Hanrath MA; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands., Banken E; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands.; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., van den Wildenberg SAH; Department of Clinical Chemistry, Catharina Hospital, Eindhoven, the Netherlands.; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands., van de Kerkhof D; Department of Clinical Chemistry, Catharina Hospital, Eindhoven, the Netherlands.; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands., Moes DJAR; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands., Boisdron-Celle M; Department of Oncopharmacology-Pharmacogenetics INSERM U892, Western Cancer Institute Paul Papin, Angers, France., van den Bosch BJC; Department of Clinical Genetics, Clinical Genomics, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands., Bax R; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands., Bet PM; Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Center, Amsterdam, the Netherlands., Maring JG; Department of Clinical Pharmacy, Isala, Zwolle, the Netherlands., Creemers GM; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands., van Hellemond IEG; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands., Deenen MJ; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands. maarten.deenen@catharinaziekenhuis.nl.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands. maarten.deenen@catharinaziekenhuis.nl.
Source: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2025 Feb 15; Vol. 95 (1), pp. 34. Date of Electronic Publication: 2025 Feb 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE
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  Data: Thymine as potential biomarker to predict 5-FU systemic exposure in patients with gastro-intestinal cancer: a prospective pharmacokinetic study (FUUT-trial).
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  Data: <searchLink fieldCode="AU" term="%22Hanrath+MA%22">Hanrath MA</searchLink>; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Banken+E%22">Banken E</searchLink>; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands.; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Wildenberg+SAH%22">van den Wildenberg SAH</searchLink>; Department of Clinical Chemistry, Catharina Hospital, Eindhoven, the Netherlands.; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Kerkhof+D%22">van de Kerkhof D</searchLink>; Department of Clinical Chemistry, Catharina Hospital, Eindhoven, the Netherlands.; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Moes+DJAR%22">Moes DJAR</searchLink>; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Boisdron-Celle+M%22">Boisdron-Celle M</searchLink>; Department of Oncopharmacology-Pharmacogenetics INSERM U892, Western Cancer Institute Paul Papin, Angers, France.<br /><searchLink fieldCode="AU" term="%22van+den+Bosch+BJC%22">van den Bosch BJC</searchLink>; Department of Clinical Genetics, Clinical Genomics, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bax+R%22">Bax R</searchLink>; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bet+PM%22">Bet PM</searchLink>; Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Maring+JG%22">Maring JG</searchLink>; Department of Clinical Pharmacy, Isala, Zwolle, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Creemers+GM%22">Creemers GM</searchLink>; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Hellemond+IEG%22">van Hellemond IEG</searchLink>; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Deenen+MJ%22">Deenen MJ</searchLink>; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands. maarten.deenen@catharinaziekenhuis.nl.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands. maarten.deenen@catharinaziekenhuis.nl.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>7806519 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0843 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203445704%22">03445704 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Chemother Pharmacol <i>Subsets: </i>MEDLINE
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