REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling.

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Title: REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling.
Authors: Ren X; Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China., Teng Y; Department of Pathology, Nanjing Medical University, Nanjing, 211166, China., Xie K; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, 211166, China., He X; Department of Pathology, Nanjing Medical University, Nanjing, 211166, China.; Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China., Chen G; Department of Pathology, Nanjing Medical University, Nanjing, 211166, China.; Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China., Zhang K; Department of Pathophysiology, Nanjing Medical University, Nanjing, 211166, China., Liao Q; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Zhang J; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, 211166, China., Zhou X; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, 211166, China., Zhu Y; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, 211166, China., Song W; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, 211166, China., Lin Y; Department of Pathology, Nanjing Medical University, Nanjing, 211166, China., Zhang Y; Department of Pathology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, 210009, China., Xu Z; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Maeshige N; Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Kobe, Hyogo, 654-0142, Japan., Liang X; Department of Pathophysiology, Nanjing Medical University, Nanjing, 211166, China., Su D; Department of Pathology, Nanjing Medical University, Nanjing, 211166, China. sudongming@njmu.edu.cn., Sun P; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, 211166, China. sunpeng@njmu.edu.cn., Ding Y; Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. dingying@njmu.edu.cn.
Source: Cell communication and signaling : CCS [Cell Commun Signal] 2025 Feb 18; Vol. 23 (1), pp. 96. Date of Electronic Publication: 2025 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1478-811X
DOI:10.1186/s12964-025-02103-4