Dysfunctional CD11c-CD21- extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer.
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| Title: | Dysfunctional CD11c-CD21- extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer. |
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| Authors: | Ruffin AT; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Casey AN; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; Molecular Genetics and Developmental Biology Graduate Program, Pittsburgh, PA 15213, USA., Kunning SR; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., MacFawn IP; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Liu Z; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Arora C; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Rohatgi A; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Kemp F; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Lampenfeld C; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Somasundaram A; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Rappocciolo G; Prellis Biologics, Berkeley, CA 94710, USA., Kirkwood JM; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Duvvuri U; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Seethala R; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Bao R; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Huang Y; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Pharmaceutical Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Cillo AR; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Center for Systems Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Ferris RL; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Bruno TC; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2025 Feb 19; Vol. 17 (786), pp. eadh1315. Date of Electronic Publication: 2025 Feb 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adh1315 |
