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Dysfunctional CD11c-CD21- extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer.

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Title: Dysfunctional CD11c-CD21- extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer.
Authors: Ruffin AT; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Casey AN; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; Molecular Genetics and Developmental Biology Graduate Program, Pittsburgh, PA 15213, USA., Kunning SR; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., MacFawn IP; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Liu Z; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Arora C; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Rohatgi A; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Kemp F; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Lampenfeld C; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Somasundaram A; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Rappocciolo G; Prellis Biologics, Berkeley, CA 94710, USA., Kirkwood JM; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Duvvuri U; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Seethala R; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Bao R; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Huang Y; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Pharmaceutical Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Cillo AR; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Center for Systems Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Ferris RL; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Bruno TC; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Feb 19; Vol. 17 (786), pp. eadh1315. Date of Electronic Publication: 2025 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dysfunctional CD11c<superscript>-</superscript>CD21<superscript>-</superscript> extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer.
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  Data: <searchLink fieldCode="AU" term="%22Ruffin+AT%22">Ruffin AT</searchLink>; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Casey+AN%22">Casey AN</searchLink>; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; Molecular Genetics and Developmental Biology Graduate Program, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Kunning+SR%22">Kunning SR</searchLink>; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22MacFawn+IP%22">MacFawn IP</searchLink>; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Arora+C%22">Arora C</searchLink>; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Rohatgi+A%22">Rohatgi A</searchLink>; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Kemp+F%22">Kemp F</searchLink>; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Lampenfeld+C%22">Lampenfeld C</searchLink>; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Somasundaram+A%22">Somasundaram A</searchLink>; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Rappocciolo+G%22">Rappocciolo G</searchLink>; Prellis Biologics, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Kirkwood+JM%22">Kirkwood JM</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Duvvuri+U%22">Duvvuri U</searchLink>; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Seethala+R%22">Seethala R</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Bao+R%22">Bao R</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Pharmaceutical Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Cillo+AR%22">Cillo AR</searchLink>; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Center for Systems Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Ferris+RL%22">Ferris RL</searchLink>; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Bruno+TC%22">Bruno TC</searchLink>; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Feb 19; Vol. 17 (786), pp. eadh1315. <i>Date of Electronic Publication: </i>2025 Feb 19.
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