Cryo-EM reveals a new allosteric binding site at the M5 mAChR.

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Bibliographic Details
Title: Cryo-EM reveals a new allosteric binding site at the M5 mAChR.
Authors: Burger WAC; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; These authors contributed equally: Wessel A. C. Burger, Jesse I Mobbs, Bhavika Rana, Jinan Wang., Mobbs JI; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; These authors contributed equally: Wessel A. C. Burger, Jesse I Mobbs, Bhavika Rana, Jinan Wang., Rana B; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; These authors contributed equally: Wessel A. C. Burger, Jesse I Mobbs, Bhavika Rana, Jinan Wang., Wang J; Computational Medicine Program and Department of Pharmacology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, United States.; These authors contributed equally: Wessel A. C. Burger, Jesse I Mobbs, Bhavika Rana, Jinan Wang., Joshi K; Computational Medicine Program and Department of Pharmacology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, United States., Gentry PR; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Yeasmin M; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Venugopal H; Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, Victoria, Australia., Bender AM; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery and Department of Chemistry, Vanderbilt University, Nashville, United States., Lindsley CW; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery and Department of Chemistry, Vanderbilt University, Nashville, United States., Miao Y; Computational Medicine Program and Department of Pharmacology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, United States., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Neuromedicines Discovery Centre, Monash University, Parkville, Australia., Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Thal DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Feb 08. Date of Electronic Publication: 2025 Feb 08.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.02.05.636602