Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA.
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| Title: | Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA. |
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| Authors: | Shin Y; Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Center for Structural Biology, The Pennsylvania State University, University Park, Pennsylvania, USA., Hedglin M; Department of Chemistry, The Center for Structural Biology, The Pennsylvania State University, University Park, Pennsylvania, USA. Electronic address: muh218@psu.edu., Murakami KS; Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Center for Structural Biology, The Pennsylvania State University, University Park, Pennsylvania, USA. Electronic address: kum14@psu.edu. |
| Source: | The Journal of biological chemistry [J Biol Chem] 2025 Apr; Vol. 301 (4), pp. 108342. Date of Electronic Publication: 2025 Feb 22. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1083-351X |
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| DOI: | 10.1016/j.jbc.2025.108342 |
