Microneedle-mediated intracochlear injection safely achieves higher perilymphatic dexamethasone concentration than intratympanic delivery in guinea pig.
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| Title: | Microneedle-mediated intracochlear injection safely achieves higher perilymphatic dexamethasone concentration than intratympanic delivery in guinea pig. |
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| Authors: | Voruz F; Department of Mechanical Engineering, Columbia University, New York City, USA.; Department of Otolaryngology-Head and Neck Surgery, New York-Presbyterian / Columbia University Irving Medical Center, New York City, USA., Feng SJ; Department of Mechanical Engineering, Columbia University, New York City, USA.; Columbia University Vagelos College of Physicians and Surgeons, New York City, USA., Breil E; Department of Mechanical Engineering, Columbia University, New York City, USA.; Department of Otolaryngology-Head and Neck Surgery, New York-Presbyterian / Columbia University Irving Medical Center, New York City, USA., Yu M; Department of Otolaryngology-Head and Neck Surgery, New York-Presbyterian / Columbia University Irving Medical Center, New York City, USA., Hammer DR; Department of Mechanical Engineering, Columbia University, New York City, USA., Aksit A; Department of Mechanical Engineering, Columbia University, New York City, USA., Zandkarimi F; Mass Spectrometry Core Facility, Department of Chemistry, Columbia University, New York City, USA., Olson ES; Department of Otolaryngology-Head and Neck Surgery, New York-Presbyterian / Columbia University Irving Medical Center, New York City, USA.; Department of Biomedical Engineering, Columbia University, New York City, USA., Kysar JW; Department of Mechanical Engineering, Columbia University, New York City, USA.; Department of Otolaryngology-Head and Neck Surgery, New York-Presbyterian / Columbia University Irving Medical Center, New York City, USA., Lalwani AK; Department of Mechanical Engineering, Columbia University, New York City, USA. akl2144@cumc.columbia.edu.; Department of Otolaryngology-Head and Neck Surgery, New York-Presbyterian / Columbia University Irving Medical Center, New York City, USA. akl2144@cumc.columbia.edu.; Department of Otolaryngology-Head & Neck Surgery, New York-Presbyterian / Columbia University Irving Medical Center, Associate Dean for Student Research, Columbia University Vagelos College of Physicians & Surgeons, 180 Fort Washington Avenue, HP8, New York, NY, 10032, USA. akl2144@cumc.columbia.edu. |
| Source: | Drug delivery and translational research [Drug Deliv Transl Res] 2025 Oct; Vol. 15 (10), pp. 3595-3606. Date of Electronic Publication: 2025 Feb 26. |
| Publication Type: | Journal Article; Comparative Study |
| Journal Info: | Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2190-3948 |
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| DOI: | 10.1007/s13346-025-01821-z |
