Reduced DNMT1 expression associated with TP53 promoter hypomethylation mediate enhanced granulosa cell senescence during ovarian aging.

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Title: Reduced DNMT1 expression associated with TP53 promoter hypomethylation mediate enhanced granulosa cell senescence during ovarian aging.
Authors: Guo H; Department of Obstetrics and Gynecology, the Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China., Pan SH; Hebei Key Laboratory of Maternal and Fetal Medicine, Institute of Reproductive Medicine of Shijiazhuang, the Fourth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, Hebei, China., Zhao J; Department of Gynecology, the People's Hospital of Shijiazhuang, Shijiazhuang, Hebei, China., Kong DX; Department of Endocrinology, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China., Geng CP; Hebei Key Laboratory of Maternal and Fetal Medicine, Institute of Reproductive Medicine of Shijiazhuang, the Fourth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, Hebei, China., Miao SB; Hebei Key Laboratory of Maternal and Fetal Medicine, Institute of Reproductive Medicine of Shijiazhuang, the Fourth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, Hebei, China.
Source: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2025 Dec; Vol. 41 (1), pp. 2471549. Date of Electronic Publication: 2025 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8807913 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0766 (Electronic) Linking ISSN: 09513590 NLM ISO Abbreviation: Gynecol Endocrinol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1473-0766
DOI:10.1080/09513590.2025.2471549