Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height.

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Title: Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height.
Authors: Papadopoulou A; William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Litkowski EM; VA Eastern Colorado Health Care System, Aurora, CO, USA.; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Graff M; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Smit RAJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Clinical Epidemiology, Leiden University Medical Center Leiden, Leiden, NL, The Netherlands.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chittoor G; Department of Population Health Sciences, Geisinger, Danville, PA, USA., Dinsmore I; Department of Genomic Health, Geisinger, Danville, PA, USA., Josyula NS; Department of Population Health Sciences, Geisinger, Danville, PA, USA., Lin M; Colorado Center for Personalized Medicine, Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, USA., Shortt J; Colorado Center for Personalized Medicine, Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, USA., Zhu W; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Vedantam SL; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA., Yengo L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Wood AR; Department of Biomedical Science, Centre of Membrane Interactions and Dynamics, University of Sheffield, Western Bank, Sheffield, UK., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Holm IA; Division of Genetics and Genomics and Manton Center for Orphan Diseases Research, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Mentch FD; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Hakonarson H; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kiryluk K; Department of Medicine, Division of Nephrology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Weng C; Department of Biomedical Informatics, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Jarvik GP; Department of Medicine (Medical Genetics) and Genome Sciences, University of Washington Medical Center, Seattle, WA, USA., Crosslin D; Division of Biomedical Informatics and Genomics, John W. Deming Department of Medicine, Tulane University, School of Medicine, New Orleans, LA, USA., Carrell D; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Kullo IJ; Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA., Dikilitas O; Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA., Hayes MG; Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Wei W-; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Edwards DRV; Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA., Assimes TL; VA Palo Alto Health Care System, Palo Alto, CA, USA., Hirschhorn JN; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Boston, MA, USA.; Departments of Genetics and Pediatrics Harvard Medical School, Boston, MA, USA., Below JE; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Gignoux CR; Colorado Center for Personalized Medicine, Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, USA., Justice AE; Department of Population Health Sciences, Geisinger, Danville, PA, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sun YV; Atlanta VA Health Care System, Decatur, GA, USA.; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA., Raghavan S; VA Eastern Colorado Health Care System, Aurora, CO, USA.; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Deloukas P; William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Marouli E; William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. e.marouli@qmul.ac.uk.; Digital Environment Research Institute, Queen Mary University of London, London, UK. e.marouli@qmul.ac.uk.
Source: NPJ genomic medicine [NPJ Genom Med] 2025 Feb 27; Vol. 10 (1), pp. 14. Date of Electronic Publication: 2025 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature in partnership with the Center of Excellence in Genomic Medicine Research at King Abdulaziz University Country of Publication: England NLM ID: 101685193 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-7944 (Electronic) Linking ISSN: 20567944 NLM ISO Abbreviation: NPJ Genom Med Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2056-7944
DOI:10.1038/s41525-025-00464-w