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Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adults.

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Title: Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adults.
Authors: Abouyannis M; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, UK; KEMRI-Wellcome Research Programme, Kilifi, Kenya. Electronic address: Michael.Abouyannis@lstmed.ac.uk., Nyambura YK; KEMRI-Wellcome Research Programme, Kilifi, Kenya., Ngome S; KEMRI-Wellcome Research Programme, Kilifi, Kenya., Riako D; KEMRI-Wellcome Research Programme, Kilifi, Kenya., Musyoki J; KEMRI-Wellcome Research Programme, Kilifi, Kenya., Muiruri C; KEMRI-Wellcome Research Programme, Kilifi, Kenya., Orindi B; KEMRI-Wellcome Research Programme, Kilifi, Kenya., Else L; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK., Amara A; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK., Dickinson L; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK., Clare RH; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, UK., Albulescu LO; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, UK., Westhorpe AP; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, UK., Kool J; Division of BioAnalytical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands; Centre for Analytical Sciences Amsterdam (CASA), 1098 XH, Amsterdam, the Netherlands., Adetifa I; KEMRI-Wellcome Research Programme, Kilifi, Kenya; Department of Infectious Diseases Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Ndungu FM; KEMRI-Wellcome Research Programme, Kilifi, Kenya., FitzGerald R; NIHR Royal Liverpool and Broadgreen CRF, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Khoo S; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK; NIHR Royal Liverpool and Broadgreen CRF, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Lalloo DG; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, UK., Casewell NR; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, UK., Hamaluba M; KEMRI-Wellcome Research Programme, Kilifi, Kenya; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Source: EBioMedicine [EBioMedicine] 2025 Mar; Vol. 113, pp. 105600. Date of Electronic Publication: 2025 Feb 27.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2352-3964
DOI:10.1016/j.ebiom.2025.105600