Rationally designed peptides inhibit the formation of α-synuclein fibrils and oligomers.

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Title: Rationally designed peptides inhibit the formation of α-synuclein fibrils and oligomers.
Authors: Ali TT; Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, University of Göttingen, Grisebachstr. 8, 37077, Göttingen, Germany., Merghani M; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Waldweg 33, 37073, Göttingen, Germany., Al-Azzani M; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Waldweg 33, 37073, Göttingen, Germany., Gatzemeier LM; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Waldweg 33, 37073, Göttingen, Germany., Hoppert M; Department of General Microbiology, Institute of Microbiology and Genetics, University of Göttingen, Grisebachstr. 8, 37077, Göttingen, Germany., Kaloyanova D; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, the Netherlands., Outeiro TF; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Waldweg 33, 37073, Göttingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075, Göttingen, Germany; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK; Max Planck Institute for Multidisciplinary Sciences, Am Faßberg 11, 37077, Göttingen, Germany., Neumann P; Department of Molecular Structural Biology, Institute of Microbiology & Genetics, University of Göttingen, Justus-von-Liebig-Weg 11, 37077, Göttingen, Germany., Popova B; Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, University of Göttingen, Grisebachstr. 8, 37077, Göttingen, Germany. Electronic address: bpopova@gwdg.de., Braus GH; Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, University of Göttingen, Grisebachstr. 8, 37077, Göttingen, Germany. Electronic address: gbraus@gwdg.de.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117452. Date of Electronic Publication: 2025 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1768-3254
DOI:10.1016/j.ejmech.2025.117452