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Multimodal histopathologic models stratify hormone receptor-positive early breast cancer.

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Title: Multimodal histopathologic models stratify hormone receptor-positive early breast cancer.
Authors: Boehm KM; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, 323 E 61 St, New York, NY, USA.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., El Nahhas OSM; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fetscherstraße 74, 01307, Dresden, Germany.; StratifAI GmbH, Suite 14500 Großenhainer Str. 98, 01127, Dresden, Germany., Marra A; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA.; Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti 435, 20141, Milan, Italy., Waters M; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, 323 E 61 St, New York, NY, USA., Jee J; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, 323 E 61 St, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., Braunstein L; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., Schultz N; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, 323 E 61 St, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA.; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., Selenica P; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., Wen HY; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., Weigelt B; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., Paul ED; MultiplexDX, s.r.o., Ilkovičova 8, 841 04 Karlova Ves, Comenius University Science Park, Bratislava, Slovakia.; MultiplexDX, Inc., One Research Court Suite 450, Rockville, MD, 20850, USA., Cekan P; MultiplexDX, s.r.o., Ilkovičova 8, 841 04 Karlova Ves, Comenius University Science Park, Bratislava, Slovakia.; MultiplexDX, Inc., One Research Court Suite 450, Rockville, MD, 20850, USA., Erber R; Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Krankenhausstraße 8-10, 91054, Erlangen, Germany., Loeffler CML; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fetscherstraße 74, 01307, Dresden, Germany., Guerini-Rocco E; Department of Pathology, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti 435, 20141, Milan, Italy.; Department of Oncology and Haemato-Oncology, University of Milano, Via Festa del Perdono 7, 20122, Milan, Italy., Fusco N; Department of Pathology, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti 435, 20141, Milan, Italy.; Department of Oncology and Haemato-Oncology, University of Milano, Via Festa del Perdono 7, 20122, Milan, Italy., Frascarelli C; Department of Pathology, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti 435, 20141, Milan, Italy.; Department of Oncology and Haemato-Oncology, University of Milano, Via Festa del Perdono 7, 20122, Milan, Italy., Mane E; Department of Pathology, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti 435, 20141, Milan, Italy., Munzone E; Division of Medical Senology, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti 435, 20141, Milan, Italy., Dellapasqua S; Division of Medical Senology, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti 435, 20141, Milan, Italy., Zagami P; Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti 435, 20141, Milan, Italy.; Department of Oncology and Haemato-Oncology, University of Milano, Via Festa del Perdono 7, 20122, Milan, Italy., Curigliano G; Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti 435, 20141, Milan, Italy.; Department of Oncology and Haemato-Oncology, University of Milano, Via Festa del Perdono 7, 20122, Milan, Italy., Razavi P; Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., Reis-Filho JS; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA.; AstraZeneca, 1 MedImmune Way, Gaithersburg, MD, 20878, USA., Pareja F; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., Chandarlapaty S; Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA. chandars@mskcc.org.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA. chandars@mskcc.org., Shah SP; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, 323 E 61 St, New York, NY, USA. shahs3@mskcc.org., Kather JN; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fetscherstraße 74, 01307, Dresden, Germany. jakob_nikolas.kather@tu-dresden.de.; Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. jakob_nikolas.kather@tu-dresden.de.
Source: Nature communications [Nat Commun] 2025 Mar 02; Vol. 16 (1), pp. 2106. Date of Electronic Publication: 2025 Mar 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-57283-x