A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations.

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Title: A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations.
Authors: Lee S; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX., Miller CL; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Brown MR; Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX., Nagarajan P; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden., Morrison J; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA., Schwander K; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO., Westerman K; Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA., Kho M; Graduate School of Data Science, Seoul National University, Seoul., Kraja AT; University of Mississippi Medical Center, Jackson, MS., de Vries PS; Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX., Ammous F; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Aschard H; Department of Computational Biology, F-75015 Paris, France Institut Pasteur, Université Paris Cité, Paris., Bartz TM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Do A; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO., Dupont CT; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO., Gudmundsdottir V; Icelandic Heart Association, Kopavogur., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Harris SE; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh., Hikino K; Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa., Huang Z; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA., Lefevre C; Department of Data Sciences, Hunter Medical Research Institute, New Lambton Heights, NSW., Lyytikäinen LP; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Tampere University, Tampere., Milaneschi Y; Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam., Nardone GG; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste., Santin A; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste., Schmidt H; Department of Molecular Biology and Biochemistry, Medical University Graz, Graz, Styria., Shen B; Laboratory of Epidemiology and Population Sciences, Health Disparities Research Section, National Institute on Aging, National Institutes of Health, Baltimore, MD., Sofer T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA., Sun Q; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Tan YA; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore., Tang J; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Thériault S; Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, QC., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen., Ware EB; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald., Ya Xing W; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, Beijing., Yu C; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC., Zhao W; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Ansari MAY; Department of Data Science, University of Mississippi Medical Center, Jackson, MS., Anugu P; Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS., Attia JR; School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW., Bazzano LA; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Breyer M; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Cade B; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA., Chen G; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Collins S; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Corley J; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh., Davies G; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh., Dörr M; German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald., Du J; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Edwards TL; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Faquih T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Fohner AE; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Fretts AM; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA., Gangireddy S; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN., Gepner A; Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Graff M; Cardiovascular Disease (CVD) Genetic Epidemiology Laboratory, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC., Hofer E; Department of Neurology, Medical University Graz, Graz, Styria., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald., Hood MM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Jie X; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, Beijing., Kähönen M; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere., Kardia SL; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Karvonen-Gutierrez CA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Launer LJ; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD., Levy D; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Maheshwari M; Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA., Martin LW; Department of Cardiology, George Washington University, Washington, DC., Matsuda K; Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo., McNeil JJ; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen., Okochi T; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC., Raitakari OT; Centre for Population Health Research, Department of Clinical Physiology and Nuclear Medicine, InFLAMES Research Flagship, Turku University Hospital and University of Turku, Turku., Risch L; Faculty of Medical Sciences , Institute for Laboratory Medicine, Private University in the Principality of Liechtenstein, Vaduz., Risch M; Central Laboratory, Cantonal Hospital Graubünden, Chur., Roux AD; Urban Health Collaborative, Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA., Ruiz-Narvaez EA; Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI., Russ TC; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh., Saito T; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi., Schreiner PJ; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN., Scott RJ; School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW., Shikany J; Division of General Internal Medicine and Population Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen., Spedicati B; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore., Taylor AM; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Tesolin P; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore., Wang R; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen., Wenbin W; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, Beijing., Xie T; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Young KL; Cardiovascular Disease (CVD) Genetic Epidemiology Laboratory, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC., Zhang R; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA., Zonderman AB; Laboratory of Epidemiology and Population Sciences, Health Disparities Research Section, National Institute on Aging, National Institutes of Health, Baltimore, MD., Concas MP; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste., Conen D; Population Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON., Cox SR; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh., Evans MK; Laboratory of Epidemiology and Population Sciences, Health Disparities Research Section, National Institute on Aging, National Institutes of Health, Baltimore, MD., Fox ER; Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS., de Las Fuentes L; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO., Giri A; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Girotto G; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Mecklenburg-Western Pomerania., Gu C; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO., Gudnason V; Icelandic Heart Association, Kopavogur., Harlow SD; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Holliday E; School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW., Jost JB; Rothschild Foundation Hospital, Institut Français de Myopie, Paris., Lacaze P; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC., Lee S; Graduate School of Data Science, Seoul National University, Seoul., Lehtimäki T; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Tampere University, Tampere., Li C; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Morrison AC; Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX., North KE; Cardiovascular Disease (CVD) Genetic Epidemiology Laboratory, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC., Penninx BW; Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Province MM; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Redline S; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Schmidt R; Department of Neurology, Medical University Graz, Graz, Styria., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore., Terao C; The Clinical Research Center at Shizuoka General Hospital, Shizuoka., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio., Franceschini N; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC., O'Connell JR; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Jaquish CE; Division of Cardiovascular Science, Epidemiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Wang H; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA., Manning A; Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA., Munroe PB; Clinical Pharmacology and Precision Medicine, Queen Mary University of London, London., Rao DC; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO., Chen H; Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX., Gauderman WJ; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA., Bierut L; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg., Fornage M; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX.
Corporate Authors: Biobank Japan Project, Lifelines Cohort Study
Source: Research square [Res Sq] 2025 Feb 17. Date of Electronic Publication: 2025 Feb 17.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2693-5015
DOI:10.21203/rs.3.rs-6025759/v1