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Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody.

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Title: Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody.
Authors: Ständer SHD; Protein Analysis Group, Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark., Reboul CF; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia.; National Institutes of Health, National Cancer Institute-Frederick Campus, Fredrick, MD, USA., Le SN; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Williams DE; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Chandler PG; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Costa MGS; Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Hoke DE; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Jimma JDT; Protein Analysis Group, Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark., Fodor J; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; The Centre for Brain, Mind and Markets, The University of Melbourne, Melbourne, VIC, Australia., Fenalti G; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Mannering SI; Immunology and Diabetes Unit, St. Vincent's Institute of Medical Research, Fitzroy, Melbourne, VIC, Australia., Porebski BT; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Schofield P; Garvan Institute of Medical Research, UNSW Sydney, Darlinghurst, NSW, Australia., Christ D; Garvan Institute of Medical Research, UNSW Sydney, Darlinghurst, NSW, Australia., Buckle M; LBPA, ENS de Paris-Saclay, UMR 8113 CNRS, Université Paris-Saclay 4, Gif-sur-Yvette, France., McGowan S; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Elmlund D; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia., Rand KD; Protein Analysis Group, Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark. kasper.rand@sund.ku.dk., Buckle AM; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. ashley.buckle@monash.edu.; San Diego Biomedical Research Institute, San Diego, CA, USA. ashley.buckle@monash.edu.
Source: Nature communications [Nat Commun] 2025 Mar 07; Vol. 16 (1), pp. 2275. Date of Electronic Publication: 2025 Mar 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody.
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  Data: <searchLink fieldCode="AU" term="%22Ständer+SHD%22">Ständer SHD</searchLink>; Protein Analysis Group, Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Reboul+CF%22">Reboul CF</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia.; National Institutes of Health, National Cancer Institute-Frederick Campus, Fredrick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Le+SN%22">Le SN</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Williams+DE%22">Williams DE</searchLink>; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Chandler+PG%22">Chandler PG</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Costa+MGS%22">Costa MGS</searchLink>; Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Hoke+DE%22">Hoke DE</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Jimma+JDT%22">Jimma JDT</searchLink>; Protein Analysis Group, Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Fodor+J%22">Fodor J</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; The Centre for Brain, Mind and Markets, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Fenalti+G%22">Fenalti G</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Mannering+SI%22">Mannering SI</searchLink>; Immunology and Diabetes Unit, St. Vincent's Institute of Medical Research, Fitzroy, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Porebski+BT%22">Porebski BT</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Schofield+P%22">Schofield P</searchLink>; Garvan Institute of Medical Research, UNSW Sydney, Darlinghurst, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Christ+D%22">Christ D</searchLink>; Garvan Institute of Medical Research, UNSW Sydney, Darlinghurst, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Buckle+M%22">Buckle M</searchLink>; LBPA, ENS de Paris-Saclay, UMR 8113 CNRS, Université Paris-Saclay 4, Gif-sur-Yvette, France.<br /><searchLink fieldCode="AU" term="%22McGowan+S%22">McGowan S</searchLink>; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Elmlund+D%22">Elmlund D</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Rand+KD%22">Rand KD</searchLink>; Protein Analysis Group, Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark. kasper.rand@sund.ku.dk.<br /><searchLink fieldCode="AU" term="%22Buckle+AM%22">Buckle AM</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. ashley.buckle@monash.edu.; San Diego Biomedical Research Institute, San Diego, CA, USA. ashley.buckle@monash.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Mar 07; Vol. 16 (1), pp. 2275. <i>Date of Electronic Publication: </i>2025 Mar 07.
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