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SR-A3 suppresses AKT activation to protect against MAFLD by inhibiting XIAP-mediated PTEN degradation.

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Title: SR-A3 suppresses AKT activation to protect against MAFLD by inhibiting XIAP-mediated PTEN degradation.
Authors: Lai P; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Miao G; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China., Zhao Y; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Han Y; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Li Y; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China., Liu Y; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing, China., Guo J; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Zhang W; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Guo X; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China., Xu Y; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Zhang L; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Chen G; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Zhou Z; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Mei S; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Chen J; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Chen J; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Xu L; Peking University Medical and Health Analysis Center, Peking University, Beijing, China., Zhang C; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China., Ding Y; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China., Dou X; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China., Wen S; NGGT (Suzhou) Biotechnology Co. Ltd, Suzhou, China., Lam SM; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.; Lipidall Technologies Company Limited, Changzhou, 213022, Jiangsu Province, China., Shui G; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., Wang Y; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Huang W; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Zhao D; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing, China., Xian X; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China. xianxunde@bjmu.edu.cn.; Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Beijing, China. xianxunde@bjmu.edu.cn.
Source: Nature communications [Nat Commun] 2025 Mar 11; Vol. 16 (1), pp. 2430. Date of Electronic Publication: 2025 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-57585-0