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SR-A3 suppresses AKT activation to protect against MAFLD by inhibiting XIAP-mediated PTEN degradation.

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Title: SR-A3 suppresses AKT activation to protect against MAFLD by inhibiting XIAP-mediated PTEN degradation.
Authors: Lai P; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Miao G; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China., Zhao Y; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Han Y; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Li Y; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China., Liu Y; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing, China., Guo J; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Zhang W; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Guo X; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China., Xu Y; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Zhang L; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Chen G; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Zhou Z; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Mei S; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Chen J; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Chen J; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Xu L; Peking University Medical and Health Analysis Center, Peking University, Beijing, China., Zhang C; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China., Ding Y; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China., Dou X; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China., Wen S; NGGT (Suzhou) Biotechnology Co. Ltd, Suzhou, China., Lam SM; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.; Lipidall Technologies Company Limited, Changzhou, 213022, Jiangsu Province, China., Shui G; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., Wang Y; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Huang W; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China., Zhao D; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing, China., Xian X; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China. xianxunde@bjmu.edu.cn.; Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Beijing, China. xianxunde@bjmu.edu.cn.
Source: Nature communications [Nat Commun] 2025 Mar 11; Vol. 16 (1), pp. 2430. Date of Electronic Publication: 2025 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: SR-A3 suppresses AKT activation to protect against MAFLD by inhibiting XIAP-mediated PTEN degradation.
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  Data: <searchLink fieldCode="AU" term="%22Lai+P%22">Lai P</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Miao+G%22">Miao G</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Guo+J%22">Guo J</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+G%22">Chen G</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Mei+S%22">Mei S</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Peking University Medical and Health Analysis Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Ding+Y%22">Ding Y</searchLink>; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Dou+X%22">Dou X</searchLink>; Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Wen+S%22">Wen S</searchLink>; NGGT (Suzhou) Biotechnology Co. Ltd, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Lam+SM%22">Lam SM</searchLink>; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.; Lipidall Technologies Company Limited, Changzhou, 213022, Jiangsu Province, China.<br /><searchLink fieldCode="AU" term="%22Shui+G%22">Shui G</searchLink>; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhao+D%22">Zhao D</searchLink>; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xian+X%22">Xian X</searchLink>; Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China. xianxunde@bjmu.edu.cn.; Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Beijing, China. xianxunde@bjmu.edu.cn.
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