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Afucosylated broadly neutralizing antibodies targeting the HIV envelope elicit enhanced NK-cell-mediated cytotoxicity against HIV-infected CD4+ T-cell and macrophage targets.

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Title: Afucosylated broadly neutralizing antibodies targeting the HIV envelope elicit enhanced NK-cell-mediated cytotoxicity against HIV-infected CD4+ T-cell and macrophage targets.
Authors: Wilhelm O; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St, Melbourne, VIC 3000, Australia., Jordan C; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia., Kek H; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Immunology, School of Translational Medicine, Monash University, Level 6, 99 Commercial Rd, Melbourne, VIC 3004, Australia., Brunton-O'Sullivan MM; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia., Rikard-Bell L; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St, Melbourne, VIC 3000, Australia., Ramanathan P; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St, Melbourne, VIC 3000, Australia., Chung AW; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St, Melbourne, VIC 3000, Australia., Poumbourios P; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Microbiology, Monash University, 19 Innovation Walk, Clayton, VIC 3800, Australia., Wines BD; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Immunology, School of Translational Medicine, Monash University, Level 6, 99 Commercial Rd, Melbourne, VIC 3004, Australia., Jaworowski A; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Infectious Diseases, Monash University, Level 2, 85 Commercial Rd, Melbourne, VIC 3004, Australia.; School of Health and Biomedical Sciences, RMIT University, Plenty Rd, Bundoora, VIC 3083, Australia., Hearps AC; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Infectious Diseases, Monash University, Level 2, 85 Commercial Rd, Melbourne, VIC 3004, Australia.; Department of Infectious Diseases, University of Melbourne, 792 Elizabeth St, Melbourne, VIC 3000, Australia.
Source: Journal of leukocyte biology [J Leukoc Biol] 2025 May 07; Vol. 117 (5).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Afucosylated broadly neutralizing antibodies targeting the HIV envelope elicit enhanced NK-cell-mediated cytotoxicity against HIV-infected CD4+ T-cell and macrophage targets.
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  Data: <searchLink fieldCode="AU" term="%22Wilhelm+O%22">Wilhelm O</searchLink>; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Jordan+C%22">Jordan C</searchLink>; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Kek+H%22">Kek H</searchLink>; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Immunology, School of Translational Medicine, Monash University, Level 6, 99 Commercial Rd, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Brunton-O'Sullivan+MM%22">Brunton-O'Sullivan MM</searchLink>; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Rikard-Bell+L%22">Rikard-Bell L</searchLink>; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Ramanathan+P%22">Ramanathan P</searchLink>; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Chung+AW%22">Chung AW</searchLink>; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Poumbourios+P%22">Poumbourios P</searchLink>; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Microbiology, Monash University, 19 Innovation Walk, Clayton, VIC 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Wines+BD%22">Wines BD</searchLink>; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Immunology, School of Translational Medicine, Monash University, Level 6, 99 Commercial Rd, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Jaworowski+A%22">Jaworowski A</searchLink>; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Infectious Diseases, Monash University, Level 2, 85 Commercial Rd, Melbourne, VIC 3004, Australia.; School of Health and Biomedical Sciences, RMIT University, Plenty Rd, Bundoora, VIC 3083, Australia.<br /><searchLink fieldCode="AU" term="%22Hearps+AC%22">Hearps AC</searchLink>; Life Sciences Discipline, Burnet Institute, GPO Box 284, Melbourne, VIC 3004, Australia.; Department of Infectious Diseases, Monash University, Level 2, 85 Commercial Rd, Melbourne, VIC 3004, Australia.; Department of Infectious Diseases, University of Melbourne, 792 Elizabeth St, Melbourne, VIC 3000, Australia.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8405628 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1938-3673 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207415400%22">07415400 </searchLink><i>NLM ISO Abbreviation: </i>J Leukoc Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/jleuko/qiaf033
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        Text: English
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      – TitleFull: Afucosylated broadly neutralizing antibodies targeting the HIV envelope elicit enhanced NK-cell-mediated cytotoxicity against HIV-infected CD4+ T-cell and macrophage targets.
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            – D: 07
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              Text: 2025 May 07
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