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Ki-67 expression in anti-programmed cell death protein-1 antibody-bound CD8+ T cells as a predictor of clinical benefit.

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Title: Ki-67 expression in anti-programmed cell death protein-1 antibody-bound CD8+ T cells as a predictor of clinical benefit.
Authors: Tsurui T; Division of Medical Pharmacology, Showa University Graduate School of Medicine, Tokyo, Japan.; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan.; Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa University, Tokyo, Japan., Hosonuma M; Division of Medical Pharmacology, Showa University Graduate School of Medicine, Tokyo, Japan.; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan.; Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa University, Tokyo, Japan., Sasaki A; Division of Medical Pharmacology, Showa University Graduate School of Medicine, Tokyo, Japan.; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan.; Pharmacological Research Center, Showa University, Tokyo, Japan.; Department of Surgery, Toho University Ohashi Medical Center, Tokyo, Japan., Maruyama Y; Division of Medical Pharmacology, Showa University Graduate School of Medicine, Tokyo, Japan.; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan.; Pharmacological Research Center, Showa University, Tokyo, Japan.; Department of Otorhinolaryngology-Head and Neck Surgery, Showa University School of Medicine, Tokyo, Japan., Amari Y; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan.; Pharmacological Research Center, Showa University, Tokyo, Japan.; Division of Clinical Pharmacology, Showa University Graduate School of Medicine, Tokyo, Japan.; Department of Otolaryngology, Showa University Fujigaoka Hospital, Kanagawa, Japan., Funayama E; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan.; Pharmacological Research Center, Showa University, Tokyo, Japan.; Division of Pharmacology, Showa University Graduate School of Pharmacy, Tokyo, Japan., Tajima K; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan.; Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan., Toyoda H; Division of Medical Pharmacology, Showa University Graduate School of Medicine, Tokyo, Japan.; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan.; Pharmacological Research Center, Showa University, Tokyo, Japan.; Department of Orthopedic Surgery, Showa University School of Medicine, Tokyo, Japan., Isobe J; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan.; Department of Hospital Pharmaceutics, Showa University School of Pharmacy, Tokyo, Japan., Yamazaki Y; Pharmacological Research Center, Showa University, Tokyo, Japan.; Division of Toxicology, Showa University Graduate School of Pharmacy, Tokyo, Japan., Baba Y; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan.; Department of Hematology, Showa University Fujigaoka Hospital, Kanagawa, Japan., Shida M; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan., Udaka Y; Division of Medical Pharmacology, Showa University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa University, Tokyo, Japan., Mura E; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan., Suzuki R; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan., Iriguchi N; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan., Ishiguro T; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan., Hirasawa Y; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan., Ohkuma R; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan., Shimokawa M; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan., Ariizumi H; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan., Kubota Y; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan., Horiike A; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan., Wada S; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan.; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan., Kuramasu A; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan., Tsuji M; Pharmacological Research Center, Showa University, Tokyo, Japan., Kiuchi Y; Division of Medical Pharmacology, Showa University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa University, Tokyo, Japan., Tsunoda T; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan., Yoshimura K; Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, 6-11-11 Kitakarasuyama, Setagaya-Ku, Tokyo, 157-8577, Japan. kyoshim1@med.showa-u.ac.jp.; Department of Medical Oncology, Showa University Graduate School of Medicine, Tokyo, Japan. kyoshim1@med.showa-u.ac.jp.
Source: Discover oncology [Discov Oncol] 2025 Mar 18; Vol. 16 (1), pp. 348. Date of Electronic Publication: 2025 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101775142 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6011 (Electronic) Linking ISSN: 27306011 NLM ISO Abbreviation: Discov Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2730-6011
DOI:10.1007/s12672-025-02060-x